ArticleJournal of perinatology : official journal of the California Perinatal Association2026
Influence of the dose and duration of intrapartum antibiotic prophylaxis on umbilical cord blood ampicillin levels.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo determine whether post-birth ampicillin levels in umbilical cord blood are affected by prenatal ampicillin administration dose.
methodsFrom pregnant women with Group B streptococcus (GBS) colonization, 159 cord blood samples were prospectively collected at delivery and analyzed using liquid chromatography-mass spectrometry.
resultsPharmacokinetic analysis revealed that maternal body mass index (BMI) negatively correlated with ampicillin levels of umbilical cord blood in pregnant women receiving at least 1 dose of 1-g ampicillin after a 2-g ampicillin loading dose (P = 0.005) and those who only received 2-g ampicillin(P = 0.044). The prophylaxis duration had no independent effect. Crucially, all samples exceeded bactericidal thresholds, even in women receiving only a single 2-g loading dose due to rapid delivery. The minimal concentration of ampicillin was 1.13 μg/mL in this cohort.
conclusionThe current intrapartum ampicillin regimens remain effective for preventing neonatal GBS infection regardless of maternal BMI or labor duration.
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