Evidence map›Paper›PMID 42009860›Full record

Observational studyScientific reports2026

Risk of stroke following SARS-CoV-2 infection in a nationwide self-controlled case series study in qatar.

Hiam Chemaitelly, Naveed Akhtar, Salman Al Jerdi, Saadat Kamran, Sujatha Joseph, Deborah Morgan, Ryan Uy, Fatma Ben Abid, Abdullatif Al-Khal, Abdul-Badi Abou-Samra and 2 more

Abstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hiam ChemaitellyInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar. hsc2001@qatar-med.cornell.edu.
Naveed AkhtarNeurosciences Institute, Hamad Medical Corporation, Doha, Qatar.
Salman Al JerdiNeurosciences Institute, Hamad Medical Corporation, Doha, Qatar.
Saadat KamranNeurosciences Institute, Hamad Medical Corporation, Doha, Qatar.
Sujatha JosephNeurosciences Institute, Hamad Medical Corporation, Doha, Qatar.
Deborah MorganNeurosciences Institute, Hamad Medical Corporation, Doha, Qatar.
Ryan UyNeurosciences Institute, Hamad Medical Corporation, Doha, Qatar.
Fatma Ben AbidDepartment of Medical Education, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar.
Abdullatif Al-KhalInfectious Disease Division, Hamad Medical Corporation, Doha, Qatar.
Abdul-Badi Abou-SamraCorporate Quality and Patient Safety Department, Hamad Medical Corporation, Doha, Qatar.
Adeel A ButtDepartment of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, USA.
Laith J Abu-RaddadInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar.

Funding

Qatar Research Development and Innovation Council ARG02-0402-240119
6 · The paper itself

Abstract

This study investigated stroke incidence after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using Qatar’s nationwide stroke registry linked with national testing, vaccination, and mortality databases. A self-controlled case series design was implemented among individuals with stroke and confirmed primary SARS-CoV-2 infection between January 1, 2020, and April 11, 2023. Incidence rate ratios (IRRs) comparing stroke incidence rate during the 1–90 days post-infection with predefined control periods were estimated using conditional Poisson regression. Of 4,187 stroke cases, 338 with confirmed infection met inclusion criteria. Stroke incidence rate was elevated during the 1–90 days post-infection (IRR 1.84, 95% CI: 1.31–2.58), peaking at days 1–28 (IRR 2.22, 95% CI: 1.53–3.22) and declining thereafter (days 29–59: IRR 1.47, 95% CI: 0.97–2.24; days 60–90: IRR 0.72, 95% CI: 0.43–1.21). This corresponded to 5.9 excess strokes per 100,000 infections. Elevated risk was confined to pre-Omicron infections (IRR 2.98, 95% CI: 1.89–4.70), with no evidence of increased risk observed for Omicron infections (IRR 0.82, 95% CI: 0.46–1.45). Subtype analyses showed increased risk for ischemic stroke (IRR 1.99, 95% CI: 1.37–2.89) and cerebral venous sinus thrombosis (CVST; IRR 3.52, 95% CI: 1.15–10.78), but not hemorrhagic stroke (IRR 0.64, 95% CI: 0.16–2.51). SARS-CoV-2 infection was associated with a transient elevation in stroke risk, peaking shortly after infection and declining thereafter. Excess risk was confined to pre-Omicron infections and driven primarily by ischemic stroke, while CVST, though rare, showed the strongest relative effect.

Indexed as

COVID-19StrokeAdultAgedCase-Control StudiesFemaleHumansIncidenceMaleMiddle AgedQatarRegistriesRisk FactorsSARS-CoV-2Adverse eventCOVID-19HemorrhagicIschemicRiskThrombosis

Identifiers

PMID42009860
PMCPMC13261118

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.