ArticleScientific reports2026
Molecular epidemiological analysis of Staphylococcus aureus from hospital and food in Huai'an, Jiangsu, China, based on whole genome sequencing.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Staphylococcus aureus (S. aureus) is a major pathogen causing severe infections and foodborne illnesses worldwide. Molecular epidemiological characteristics of S. aureus exhibit substantial temporal and regional differences. This study aims to investigate the genomic epidemiology of clinical (81 isolates) and food-derived (17 isolates) S. aureus strains from Huai’an, Jiangsu, China, during 2020 to 2021. Whole-genome sequencing revealed dominant multi-locus sequence typing (MLST) types, including ST398 (18.4%), ST1 (15.3%), and ST59 (11.2%). Hospital isolates showed higher methicillin-resistant S. aureus (MRSA) prevalence (58.0% vs. 41.2% in food), although the carriage rates of antimicrobial resistance (AMR) and virulence factor (VF) genes were similar between the two sources. Staphylococcal Chromosomal Cassette mec (SCCmec) type IVa(2B) (48.1%) predominated, suggesting community-associated MRSA infiltration into healthcare settings. Biofilm-associated gene profiles varied between MRSA and methicillin-susceptible S. aureus (MSSA), with ST1-t127 strains harboring comprehensive biofilm genes. Mobile genetic elements (MGEs), particularly plasmids (38.5%) and insertion sequences (32.3%), facilitated the dissemination of AMR and VF genes. Pan-genomic analysis demonstrated an open genome structure, with core genes enriched in metabolic functions (clusters of orthologous groups [COG] categories C, E, H, and P). Phylogenetic reconstruction revealed cross-regional transmission of ST1 and ST398, including international clades, while ST59 isolates exhibited clade diversification. This study elucidates the genetic diversity of S. aureus in Huai’an, Jiangsu, China, indicating its potential for cross-transmission between food and human sources and for regional dissemination, underscoring the need for One Health surveillance to curb the spread of high-risk clones.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.