Evidence map›Paper›PMID 42009657›Full record

ArticleNature communications2026

Phage homing endonuclease amplifies anti-defense genes to evade bacterial immunity.

Kotaro Chihara, Aa Haeruman Azam, Artyom A Egorov, Ilya Terenin, Masanori Hashino, Koichi Watashi, Kazuhiro Horiba, Vasili Hauryliuk, Kotaro Kiga

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kotaro ChiharaDepartment of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.
Aa Haeruman AzamDepartment of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.
Artyom A EgorovDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Ilya TereninDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Masanori HashinoPathogen Genomics Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.
Koichi WatashiDepartment of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.ORCID 0000-0002-4536-9966
Kazuhiro HoribaPathogen Genomics Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.ORCID 0000-0003-3017-299X
Vasili HauryliukDepartment of Experimental Medical Science, Lund University, Lund, Sweden.ORCID 0000-0003-2389-5057
Kotaro KigaDepartment of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan. kiga.k@jihs.go.jp.

Funding

Japan Agency for Medical Research and Development (AMED) JP22fk0108562Japan Agency for Medical Research and Development (AMED) JP23fk0108599Japan Agency for Medical Research and Development (AMED) JP23wm0325065Japan Agency for Medical Research and Development (AMED) JP24fk0108698Japan Agency for Medical Research and Development (AMED) JP25ym0126806Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) 2020-0037Vetenskapsrådet (Swedish Research Council) 2021-01146
6 · The paper itself

Abstract

Bacteriophages must overcome diverse bacterial immune systems, yet the molecular principles enabling such escape remain poorly understood. Here, we show that the phage homing endonuclease SegB facilitates immune evasion by promoting the segmental amplification of anti-defense loci. The antiphage defense Septu inhibits phage T6 replication by cleaving the variable loop of tRNA

Indexed as

BacteriophagesEndonucleasesEscherichia coliImmune EvasionViral ProteinsVirus ReplicationEndonucleasesViral Proteins

Identifiers

PMID42009657
PMCPMC13096335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.