Evidence map›Paper›PMID 42009466›Full record

ArticleJournal of the American Chemical Society2026

Thiol-Retaining N-Terminal Cysteine Chemistry for Dual Modification and Bicyclic Peptide Construction.

Junjie Liu, Shixiang Duan, Yang Huang, Ming-Yi Jian, Hsuan Suan Lee, Gaocan Dai, Chuanliu Wu, Yi-Lin Wu, Yu-Hsuan Tsai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Junjie LiuInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518132, China.
Shixiang DuanInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518132, China.
Yang HuangGuizhou Provincial Key Laboratory of Innovation and Manufacturing for Pharmaceuticals, School of Pharmacy, Zunyi Medical University, Zunyi 563003, China.ORCID 0000-0002-7542-8074
Ming-Yi JianDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
Hsuan Suan LeeInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518132, China.ORCID 0009-0005-4744-7680
Gaocan DaiInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518132, China.
Chuanliu WuDepartment of Chemistry, College of Chemistry and Chemical Engineering, the MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, China.ORCID 0000-0003-2946-7299
Yi-Lin WuDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.ORCID 0000-0003-0253-1625
Yu-Hsuan TsaiInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518132, China.ORCID 0000-0003-0589-5088

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N-terminal cysteine presents a uniquely reactive 1,2-aminothiol motif that enables site-specific modification of peptides and proteins composed solely of canonical amino acids. For both

Indexed as

CysteinePeptidesPeptides, CyclicSulfhydryl CompoundsMolecular StructureCysteinePeptidesPeptides, CyclicSulfhydryl Compounds

Identifiers

PMID42009466
PMCPMC13154194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.