ArticleLupus science & medicine2026
Adverse childhood experiences are associated with disease and mental health outcomes in childhood-onset SLE.
Article in Lupus science & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relationship between adverse childhood experiences (ACEs) and health outcomes in childhood-onset SLE (cSLE).
methodsWe conducted a retrospective cohort study of cSLE outpatients aged 9-18 years at a Canadian tertiary centre from July 2018 to June 2020. ACEs data were collected from electronic medical records, categorised according to the US Centers for Disease Control-Kaiser framework and in relationship to time of cSLE diagnosis. Primary outcomes included disease activity, disease damage and comorbid psychiatric diagnoses (not attributable to cSLE). Secondary outcomes included neuropsychiatric SLE (NPSLE), lupus nephritis and arthritis. Regression models examined the relationship between (1) presence (yes/no) and (2) timing of ACEs (none vs before vs after cSLE diagnosis) and the outcomes. Covariates included sex, ethnicity, age at diagnosis, disease duration, nephritis/NPSLE and glucocorticoid use.
resultsOf 224 patients with cSLE, 41% had documented ACEs. The presence of ACEs was associated with NPSLE (adjusted OR=3.40, 95% CI 1.55 to 7.78, p=0.003). ACEs occurring before diagnosis were associated with disease damage (adjusted OR 3.10, 95% CI 1.21 to 8.04, p=0.018) and NPSLE (adjusted OR=2.67, 95% CI 1.02 to 6.98, p=0.043). ACEs occurring after cSLE diagnosis were associated with comorbid psychiatric diagnosis (adjusted OR=5.01, 95% CI 1.20 to 21.12, p=0.025). ACEs were not associated with disease activity, nephritis or arthritis.
conclusionACEs exposure was prevalent in this cSLE cohort, associated with NPSLE diagnosis, disease damage and comorbid psychiatric diagnoses. These findings suggest that early-life stressors may contribute to cSLE morbidity, particularly neuropsychiatric features, emphasising the importance of addressing psychosocial issues in the context of medical care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.