ArticleProceedings of the National Academy of Sciences of the United States of America2026
Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- A systematic overexpression screen identifies cytotoxic genes encoded by the Cluster L1 mycobacteriophage LeBron.G3 (Bethesda, Md.) · 2026Article
- Article
- Phage N4 uses a SAR endolysin-holin system for host cell lysis.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Most bacteriophages lyse their host cell to release progeny virions. Double-stranded DNA phages typically promote host lysis using a holin-endolysin system. Holins form pores in the cytoplasmic membrane allowing endolysins access to the peptidoglycan (PG) cell wall, which they degrade to weaken the cell envelope and promote osmotic lysis. Phages that infect Proteobacteria also encode a spanin in their lysis cassette that functions to disrupt the host outer membrane (OM). The spanin-requirement for cell lysis provided the first clue that the proteobacterial OM confers mechanical rigidity to the cell envelope. Corynebacteria and mycobacteria also build an OM, but it is made of mycolic acids instead of lipopolysaccharides. Here, we investigated whether the mycomembrane presents a mechanical barrier to phage-induced lysis of corynebacteria. In addition to annotated holin and endolysin genes, mycobacteriophages and corynephages were found to encode a membrane protein we call LysZ in their lysis cassettes. Deletion of
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