ArticleBlood transfusion = Trasfusione del sangue
Comparison between cold-stored platelets treated with riboflavin and UV light versus untreated cold-stored platelets.
Article in Blood transfusion = Trasfusione del sangue. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Cold platelets, redefined: pathogen reduction without surrendering hemostatic intent.Blood transfusion = Trasfusione del sangueArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRiboflavin and UV light-based pathogen reduction technology (PRT) and cold-stored platelets (CSP) have a significant impact on platelet (PLT) function. The aim of this study is to determine whether the use of both methods is beneficial. MATERIALS AND
methodsTwenty buffy coat (BC) PLT concentrates were grouped into 10 type-matched pairs, which were pooled and split into 10 non-PRT-treated PLTs and 10 PRT-treated PLTs, diluted in platelet additive solution (PAS-E) and leukoreduced. Both groups were cold-stored at 2-6ºC without agitation for 14 days (non-PRT CSP and PRT CSP). Hemostatic function and metabolic parameters were monitored on day 1 pre-refrigeration and on days 3, 7 and 14 of cold storage.
resultsNo swirling and no aggregates were observed at any time in either group after cold storage for 14 days. PRT CSP were less metabolically active (with better pH, lower lactate, lower pCO DISCUSSION: The enhanced hemostatic PLT function achieved by CSP, i.e., faster clot formation, is also maintained by riboflavin and UV light treatment. The combination of riboflavin and UV light-based PRT and CSP has the added benefit of reducing platelet metabolism, which may have a positive effect on PLT viability. Further research is required to assess whether the in vitro benefits of combining PRT and CSP are confirmed in clinical trials.
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