ArticleIntensive care medicine experimental2026
Refining an acute respiratory distress syndrome animal model supported by extracorporeal membrane oxygenator: incorporating clinically relevant mechanical ventilation strategy upon development.
Article in Intensive care medicine experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAcute respiratory distress syndrome (ARDS) requiring veno-venous extracorporeal membrane oxygenation (VV-ECMO) is associated with high mortality. One of the primary challenges in translating preclinical findings into effective clinical treatments lies in developing animal models that accurately replicate clinical scenarios. Thus, we aimed to develop a clinically relevant novel ovine model of severe ARDS with VV-ECMO support, with the primary aim of assessing feasibility through 48-h survival, while monitoring safety and clinical relevance.
methodsSix sheep (52.7 ± 1.5 kg) were anesthetized and mechanically ventilated. Severe ARDS was induced by oleic acid and lipopolysaccharide (0.5 µg/kg). Lung-protective mechanical ventilation commenced once the PaO
resultsAll sheep survived the 48-h follow-up. No complications were recorded throughout the study. In all sheep, although PaO
conclusionsWe developed a novel animal model of ARDS that closely replicates ARDS management, including lung-protective mechanical ventilation before the initiation of VV-ECMO, ensuring a prolonged 48-h survival observation without any complications. This model meets all four key features of ARDS as recommended by the latest ATS guidelines and provides an innovative platform to support clinical translation.
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