ReviewArchives of microbiology2026
Exploring Morchella mushrooms: a natural approach to cancer therapy.
Review in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer poses a major global health challenge, driving the continuous search for innovative treatment strategies. In that context, natural products have gained significant attention due to their recognized cytotoxic efficacy against diverse human cancer lineages. Morchella species, commonly known as morel mushrooms, stand out for their historical medicinal applications and diverse bioactive compounds. This review explores the therapeutic potential of key Morchella species, including M. esculenta, M. pulchella, M. conica, M. deliciosa, M. importuna, M. elata, M. angusticeps, and M. sextelata, in the context of cancer treatment. These species contain bioactive compounds that exhibit LC50 values as low as 0.02 mg/mL, effectively targeting molecular pathways like p53 and NRF2. These mushrooms are rich in bioactive compounds, such as polysaccharides, phenolics, alkaloids, and secondary metabolites, which exhibit promising anticancer properties. Key mechanisms of action include inducing apoptosis in cancer cells, inhibiting tumour growth and metastasis, modulating the immune system, and reducing oxidative stress through antioxidant effects. Morchella compounds show potential for synergistic use with existing chemotherapy and radiotherapy treatments, opening new avenues for integrative cancer therapies. Future research should focus on elucidating molecular pathways, optimizing formulations, and leveraging biotechnological advancements to maximize the clinical potential of Morchella species. This review underscores the importance of natural products in developing novel, effective cancer therapies and highlights the urgent need for further investigation.
Indexed as
Identifiers
42007978What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.