Evidence map›Paper›PMID 42007933›Full record

ArticleJACC. Case reports2026

Cardioneuroablation Restoring Atrioventricular Conduction in Brugada Syndrome: A Device-Free Approach.

Fredy Chipa-Ccasani, Josep Brugada, Agustín Leonardo Luján, Estefanía Martínez-Barrios, Nuria Díez-Escuté, Erika Fernanda Merchan Pinto, Oscar Campuzano, José Cruzalegui, Andrea Greco, Georgia Sarquella-Brugada

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In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fredy Chipa-CcasaniArrítmies Pediàtriques, Cardiologia Genètica I Mort Sobtada, Malalties Cardiovasculars en el Desenvolupament, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain; Pediatric Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Hospital Sant Joan de Déu, Barcelona, Spain.
Josep BrugadaArrítmies Pediàtriques, Cardiologia Genètica I Mort Sobtada, Malalties Cardiovasculars en el Desenvolupament, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain; Pediatric Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Hospital Sant Joan de Déu, Barcelona, Spain.
Agustín Leonardo LujánArrítmies Pediàtriques, Cardiologia Genètica I Mort Sobtada, Malalties Cardiovasculars en el Desenvolupament, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
Estefanía Martínez-BarriosArrítmies Pediàtriques, Cardiologia Genètica I Mort Sobtada, Malalties Cardiovasculars en el Desenvolupament, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain; Pediatric Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Hospital Sant Joan de Déu, Barcelona, Spain.
Nuria Díez-EscutéArrítmies Pediàtriques, Cardiologia Genètica I Mort Sobtada, Malalties Cardiovasculars en el Desenvolupament, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain; Pediatric Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Hospital Sant Joan de Déu, Barcelona, Spain.
Erika Fernanda Merchan PintoArrítmies Pediàtriques, Cardiologia Genètica I Mort Sobtada, Malalties Cardiovasculars en el Desenvolupament, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain; Pediatric Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Hospital Sant Joan de Déu, Barcelona, Spain.
Oscar CampuzanoSchool of Medicine, University of Girona, Girona, Spain.
José CruzaleguiArrítmies Pediàtriques, Cardiologia Genètica I Mort Sobtada, Malalties Cardiovasculars en el Desenvolupament, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain; Pediatric Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Hospital Sant Joan de Déu, Barcelona, Spain.
Andrea GrecoArrítmies Pediàtriques, Cardiologia Genètica I Mort Sobtada, Malalties Cardiovasculars en el Desenvolupament, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain; Pediatric Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Hospital Sant Joan de Déu, Barcelona, Spain.
Georgia Sarquella-BrugadaArrítmies Pediàtriques, Cardiologia Genètica I Mort Sobtada, Malalties Cardiovasculars en el Desenvolupament, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain; Pediatric Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Hospital Sant Joan de Déu, Barcelona, Spain; Pediatrics Department, School of Medicine, University of Barcelona, Barcelona, Spain. Electronic address: georgia@brugada.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBrugada syndrome (BrS), traditionally associated with ventricular arrhythmic risk, may also involve conduction disturbances. SCN5A deleterious variants predispose to bradyarrhythmias and atrioventricular block, posing the challenge of pacemaker implantation in young patients. CASE SUMMARY: A 17-year-old girl with BrS and SCN5A p.(Glu901Lys) pathogenic variant presented with recurrent presyncope, dyspnea, and more than 3,000 second-degree atrioventricular blocks documented on 24-hour Holter monitoring. Atropine administration reversed the block, confirming a functional origin. Biatrial approach cardioneuroablation (CNA) guided by electroanatomical mapping without fluoroscopy restored normal conduction and improved sinus rate. After 12 months, the patient remained asymptomatic and free of bradyarrhythmias. DISCUSSION: CNA restores autonomic balance and corrects functional bradyarrhythmias in BrS, avoiding permanent pacing. Success of CAN depends on accurate identification of the functional mechanism and expertise in autonomic mapping. TAKE-HOME MESSAGES: In BrS, vagally mediated functional bradyarrhythmias may respond to atropine testing. CNA offers a physiological and durable alternative to pacemaker implantation in young patients with functional atrioventricular block.

Indexed as

atrioventricular blockBrugada syndromecardioneuroablation

Identifiers

PMID42007933
PMCPMC13221813

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