Evidence map›Paper›PMID 42007885›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Orthogonal Ionic Liquid-Based Extraction Strategy Enables Amyloid-Specific Profiling of Aggregate Proteome.

Shiying Zheng, Ye Liu, Bowen Zhong, Huiying Chu, Zhou Gong, Baofeng Zhao, Mengchun Cheng, Zhen Liang, Yukui Zhang, Qun Zhao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shiying ZhengState Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Ye LiuInterdisciplinary Research Center for Biology and Chemistry, Liaoning Normal University, Dalian, China.
Bowen ZhongState Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Huiying ChuInterdisciplinary Research Center for Biology and Chemistry, Liaoning Normal University, Dalian, China.
Zhou GongState Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Innovation Academy for Precision Measurement Science and Technolog, Chinese Academy of Sciences, Wuhan, China.
Baofeng ZhaoState Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Mengchun ChengState Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Zhen LiangState Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Yukui ZhangState Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Qun ZhaoState Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Lihua ZhangState Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.ORCID https://orcid.org/0000-0003-2543-1547

Funding

Dalian Science Foundation for Distinguished Young Scholars 2024RJ009Innovation program of science and research from the Dalian institute of chemical physics, Chinese Academy of sciences DICP I202529 DICP I202413National Key R&D Program of China 2021YFA1301501National Key R&D Program of China 2024YFC3405403National Natural Science Foundation 22274150National Natural Science Foundation 22322411National Natural Science Foundation 22393931National Natural Science Foundation 32088101
6 · The paper itself

Abstract

Amyloid deposits, composed of insoluble cross-β-sheet fibrils, are pathological hallmarks of many neurodegenerative diseases. However, their structural heterogeneity and extreme insolubility hinder characterization of their molecular composition and deposition mechanisms. Here, an orthogonal ionic liquid-based extraction strategy (Orth-iEA) was developed to selectively enrich amyloid aggregates from complex biological samples. Systematic screening identified tetramethylguanidine tetrafluoroborate (TMGBF

Indexed as

Alzheimer DiseaseAmyloidIonic LiquidsProtein Aggregation, PathologicalProteomeProteomicsAnimalsDisease Models, AnimalHippocampusHumansMiceMice, TransgenicAmyloidIonic LiquidsProteomeamyloid depositsIonic liquidsneurodegenerative diseasesorthogonal extractionproteome

Identifiers

PMID42007885
PMCPMC13335754

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.