Evidence map›Paper›PMID 42007827›Full record

ArticleJournal of medical virology2026

Cytomegalovirus Reactivation During Therapy for Pediatric Acute Lymphoblastic Leukemia.

Archana Melavarige Venkatagiri, Neha Reddy, Rhea Chandwani, Nishanth Shekar, Swathi Perampalli Manjunath, Emine Abdu Rahiman, Chiranjay Mukhopadhyay, Vasudeva Bhat Kalya

Abstract read
In one paragraph

Article in Journal of medical virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Archana Melavarige VenkatagiriDepartment of Pediatric Oncology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Neha ReddyDepartment of Pediatric Oncology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Rhea ChandwaniDepartment of Pediatric Oncology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Nishanth ShekarDepartment of Pediatric Oncology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Swathi Perampalli ManjunathDepartment of Pediatric Oncology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Emine Abdu RahimanDepartment of Pediatric Oncology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Chiranjay MukhopadhyayDepartment of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.ORCID https://orcid.org/0000-0003-0402-1143
Vasudeva Bhat KalyaDepartment of Pediatric Oncology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.ORCID https://orcid.org/0000-0002-4081-1372

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytomegalovirus (CMV) reactivation is a recognized complication after hematopoietic stem cell transplantation, but its relevance during conventional chemotherapy for pediatric acute lymphoblastic leukemia (ALL) is poorly defined, especially in CMV-prevalent regions. This retrospective cross-sectional study was conducted at a tertiary pediatric oncology center in South India from January 2020 to August 2025. Children (≤ 18 years) with ALL who developed CMV reactivation during chemotherapy were included. CMV testing was performed based on clinical indications, and viral load was quantified using multiplex polymerase chain reaction. Demographic, clinical, laboratory, treatment, and outcome data were analyzed. Of 150 children treated for ALL, 29 (19.3%) experienced CMV reactivation. The median age was 6 years, with a male predominance (72.4%). Reactivation occurred predominantly during consolidation (51.7%) and maintenance (41.4%) phases. Fever was the most common presentation (75.9%). The median CMV viral load was 1.48 × 10

Indexed as

CytomegalovirusCytomegalovirus InfectionsPrecursor Cell Lymphoblastic Leukemia-LymphomaVirus ActivationAdolescentChildChild, PreschoolFemaleHumansIndiaInfantMaleRetrospective Studiesacute lymphoblastic leukemiachemotherapy‐related infectionsCMV reactivationcytomegaloviruslymphopeniapediatric oncology

Identifiers

PMID42007827
PMCPMC13094460

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.