Evidence map›Paper›PMID 42007819›Full record

ArticleJournal of clinical microbiology2026

A multicenter performance evaluation of aztreonam-avibactam gradient diffusion susceptibility testing for

Tina I Bui, Edith Csiki-Fejer, Sarah Prudhomme, Louise Bossy, Dwight J Hardy, Mandy Wootton, Gilles Zambardi, Melanie L Yarbrough

Abstract readMulticenter StudyEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tina I BuiDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0002-4110-3263
Edith Csiki-FejerbioMérieux Clinical Affairs, Saint Louis, Missouri, USA.ORCID 0009-0001-8910-9648
Sarah PrudhommebioMérieux Clinical Affairs, Marcy-l'Etoile, France.
Louise BossybioMérieux Clinical Affairs, Marcy-l'Etoile, France.
Dwight J HardyDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Mandy WoottonPublic Health Wales Microbiology, University Hospital of Wales, Cardiff, United Kingdom.ORCID 0000-0002-2227-3355
Gilles ZambardibioMérieux Clinical Affairs, Marcy-l'Etoile, France.
Melanie L YarbroughDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0003-2166-7552

Funding

bioMérieux
6 · The paper itself

Abstract

Aztreonam-avibactam (AZA) is a new monobactam/beta-lactamase inhibitor combination that recently received regulatory approval in the United States (U.S.) and Europe. In this study, we evaluated the performance of ETEST AZA, a gradient diffusion method, compared to reference broth microdilution for 650 challenge ( IMPORTANCE: Aztreonam-avibactam (AZA) is a novel monobactam/β-lactamase inhibitor combination approved for clinical use in the United States and Europe in 2025 and 2024, respectively. It is indicated for the treatment of multidrug-resistant Gram-negative bacteria that produce multiple classes of β-lactamases. Until recently, antimicrobial susceptibility testing for this combined agent relied on broth disk elution or microdilution using ceftazidime-avibactam and aztreonam combined. In this study, we evaluated the performance of the bioMérieux ETEST AZA gradient diffusion strip as a more streamlined method for clinical microbiology laboratories. Testing of 650

Indexed as

Anti-Bacterial AgentsAzabicyclo CompoundsAztreonambeta-Lactamase InhibitorsDisk Diffusion Antimicrobial TestsEnterobacteriaceaeDrug CombinationsEnterobacteriaceae InfectionsEuropeHumansMicrobial Sensitivity TestsUnited StatesAnti-Bacterial AgentsavibactamAzabicyclo CompoundsAztreonamaztreonam, avibactam drug combinationbeta-Lactamase InhibitorsDrug Combinationsaztreonam-avibactamEnterobacteralesETEST AZAgradient diffusion

Identifiers

PMID42007819
PMCPMC13170220

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.