ArticleArthritis care & research2026
Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow-Up: Data From the Multicenter Osteoarthritis Study.
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C Nevitt, Cora E Lewis, James C Torner, Tuhina Neogi, Multicenter Osteoarthritis Study Group
Abstract read
In one paragraphArticle in Arthritis care & research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Kristine GodziukDepartment of Physical Therapy and Rehabilitation Science, School of Medicine, University of California, San Francisco.
Sarah TilleyChobanian & Avedisian School of Medicine, Boston University, Boston, Massachusetts.
Michael LaValleyBoston University School of Public Health, Boston, Massachusetts.
Michael C NevittDepartment of Epidemiology and Biostatistics, University of California, San Francisco.
Cora E LewisDepartment of Epidemiology, University of Alabama at Birmingham.
James C TornerDepartment of Epidemiology, University of Iowa, Iowa City.
Multicenter Osteoarthritis Study Group
Funding
Project 3: Intraarticular MineralizationU19AG076471 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DAVID Tobin FELSON · 2023 to 2026
$49.0MMulticenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7MMulticenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1MMulticenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6MMulticenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2MResearch and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Michael Paul Lavalley · 2019 to 2026
$6.9MThe Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1MAlberta InnovatesNIAMS NIH HHS K24 AR070892NIAMS NIH HHS P30 AR072571NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069NIA NIH HHS U19 AG076471NIH HHS K24 AR070892NIH HHS P30 AR072571NIH HHS U01 AG18820NIH HHS U01 AG18832NIH HHS U01 AG18947NIH HHS U01 AG19079NIH HHS U19 AG076471Obesity CanadaOsteoarthritis Research Society International
6 · The paper itselfAbstract
objectiveObesity, defined by body mass index (BMI) ≥30 kg/m
methodsWe included participants from the Multicenter Osteoarthritis Study (MOST) with a BMI ≥30 kg/m
resultsOf the baseline sample (N = 1,211 individuals, 63% female, mean age 61.2 ± SD 7.6 years, mean BMI 35.0 ± SD 4.5 kg/m
conclusionIndividuals with obesity and concurrent low muscle or cardiometabolic comorbidities have persistent worse functioning over a seven-year period compared to those with obesity alone. Distinguishing obesity subtypes may enable personalized interventions to delay or avoid extended mobility disability.
Identifiers
PMID42007775
PMCPMC13159606
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