Observational studyClinical cardiology2026
Clinical Characteristics and Risk Factors of Immune Checkpoint Inhibitor-Related Myocarditis: A Real World Observational Study.
Observational study in Clinical cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A narrative review of immune checkpoint inhibitor-related cardiotoxicity in lung cancer: mechanisms, risk stratification, and clinical management.Journal of thoracic disease · 2026Review
- Clinical Characteristics and Risk Factors of Immune Checkpoint Inhibitor-Related Myocarditis: A Real World Observational Study.Clinical cardiology · 2026Observational
- Real-world insights into incidence and risk factors of thyroid dysfunction following immune checkpoint inhibitor therapy.Frontiers in immunology · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundRare occurrence, immune checkpoint inhibitors (ICI)-related myocarditis are poorly documented in the literature. RESEARCH DESIGN AND
methodsWe conducted a retrospective review of patients who had ICI until June 2023. Patient follow-up was extended until death or on May 2024. The primary outcome was the incidence of suspected ICI-related myocarditis. Logistic regression was used to investigate the associations between clinical characteristics and suspected ICI-related myocarditis.
resultsAmong the included 8199 patients, 1638 (19.98%) patients developed suspected ICI-related myocarditis. Logistic regression revealed that thymomas and thymic carcinomas (OR 2.242; [95% CI, 1.132-4.440], p = 0.021), lung cancer (OR 1.259; [95% CI, 1.119-1.416], p < 0.001), older patients (OR 1.021; [95% CI, 1.016-1.026], p < 0.001), male (OR 1.213; [95% CI, 1.061-1.388], p = 0.005), block two or more immune checkpoints (OR = 1.391 [95% CI 1.058-1.828], p = 0.018), combined with hypertension (OR = 1.326 [95% CI 1.162-1.513], p < 0.001), or hyperlipidemia (OR = 1.656 [95% CI 1.302-2.107], p < 0.001) were associated with higher risk of suspected ICI-related myocarditis.
conclusionsThis large, real-world cohort demonstrates that the incidence of suspected ICI-related myocarditis may be underestimated in previous literature. Routine cardiac surveillance is needed in high-risk patients receiving ICI therapy.
trial registrationRegistered at https://www.chictr.org.cn (identifier: ChiCTR2300075974).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.