ArticleThoracic cancer2026
Enhancing Diagnostic Pathways for Bronchopulmonary Neuroendocrine Tumors: Assessment of the South Wales Neuroendocrine Tumor Service Transformation.
Article in Thoracic cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBronchopulmonary neuroendocrine tumors (bpNETs) are uncommon lung neoplasms posing significant diagnostic and therapeutic challenges. This study evaluates the impact of the transformation of the South Wales Neuroendocrine Cancer Service on diagnostic and management outcomes for bpNETs.
methodsWe retrospectively analyzed data from patients with typical and atypical carcinoids (TC and AC) diagnosed before and after commissioned service transformation (September 2017). Data were collected from network cancer databases and clinical portals. Demographics, diagnostic pathway times, diagnostic tests, treatment modalities, and survival outcomes were analyzed.
resultsFollowing transformation, significant reductions were observed in median times from presentation to diagnosis (p = 0.009), symptom onset to diagnosis (p = 0.006), and presentation to treatment (p = 0.020). No other significant differences were noted between pre- and post-transformation groups. Incidental diagnoses increased, especially in TCs (53%). Usage of CgA, HIAA, EBUS biopsies, and Gallium PET scans increased post-transformation. Surgical treatments were common, but there was an increase in systemic therapy post-transformation.
conclusionImplementation of a collaborative care model and NET service transformation led to significant improvements in pathway times. This is one of the few studies describing such improvements in NETs. While survival outcomes showed promising trends, further research is needed to assess the long-term impact on patient outcomes.
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