Evidence map›Paper›PMID 42007677›Full record

ArticleeLife2026

Structural mechanisms of pump assembly and drug transport in the AcrAB-TolC efflux system.

Xiaofei Ge, Zhiwei Gu, Jiawei Wang

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaofei GeState Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China.ORCID https://orcid.org/0009-0005-9626-7061
Zhiwei GuState Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China.ORCID https://orcid.org/0009-0006-5573-5022
Jiawei WangState Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China.ORCID https://orcid.org/0000-0001-9893-8539

Funding

National Natural Science Foundation of China 32371254National Natural Science Foundation of China 32501078Natural Science Foundation of Beijing Municipality 5262009Science and Technology Development Fund, Macau SAR 0112/2025/ITP2
6 · The paper itself

Abstract

Tripartite multidrug efflux pumps that span the cell envelope are essential for antibiotic resistance in Gram-negative bacteria. Here, we report cryo-EM structures of two endogenous efflux complexes from

Indexed as

ATP-Binding Cassette, Sub-Family C ProteinsBacterial Outer Membrane ProteinsCarrier ProteinsEscherichia coliEscherichia coli ProteinsLipoproteinsMembrane Transport ProteinsBiological TransportCryoelectron MicroscopyModels, MolecularProtein BindingProtein ConformationAcrAB-TolC protein, E coliAcrB protein, E coliATP-Binding Cassette, Sub-Family C ProteinsBacterial Outer Membrane ProteinsCarrier ProteinsEscherichia coli ProteinsLipoproteinsMembrane Transport ProteinstolC protein, E coliAcrAAcrBantibiotic resistanceE. colimolecular biophysicsmultidrug efflux pumpstructural biologyTolCYbjP

Identifiers

PMID42007677
PMCPMC13095208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.