ArticleVeterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association2026
Effect of a Standardized Sedation Protocol on Portal Vein Velocity Measurements in Hospitalized Dogs Using Triplex-Doppler Ultrasonography.
Article in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Portal vein velocity (PVV) is a useful indirect indicator of portal pressure. Reference values for PVV have been previously established in healthy, non-sedated dogs with reported ranges of 14.7 ± 2.5 and 18.1 ± 7.6 cm/s. PVV may be influenced by physiological and pathological factors; for example, a correlation between body weight and PVV has been documented; however, the effect of other factors is unknown. The primary aims of this prospective comparative study were to investigate the effect of standardized intravenous sedation protocol of medetomidine (2-3 µg/kg) and butorphanol (0.3 mg/kg) on PVV and to determine whether post-sedation PVV results would fall below the portal hypertension threshold of 10 cm/s. Six triplex-Doppler PVV measurements were obtained pre- and post-sedation on 15 client-owned dogs undergoing abdominal ultrasonography for conditions unrelated to primary liver disease. The mean PVV pre-sedation was 14.9 ± 3.98 cm/s and 3-min post-sedation was 10.4 ± 3.73 cm/s, representing a statistically significant reduction in PVV (p < 0.001). The mean PVV was below 10 cm/s in 3/15 (20%) dogs pre-sedation and below 10 cm/s in 9/15 (60%) dogs post-sedation. There was no effect of age, sex, or weight on PVV before and/or after sedation. Sedation with medetomidine and butorphanol caused a significant reduction in PVV at 3-min post-administration. This finding should be considered when evaluating hepatic and portal hemodynamics in dogs, as 60% (9/15) of the sedated cases with presumed normal hepatic function exhibited post-sedation PVV at levels seen with portal hypertension.
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