Evidence map›Paper›PMID 42007640›Full record

ArticleChronic obstructive pulmonary diseases (Miami, Fla.)2026

Small Pulmonary Artery and Vein Volumes Independently Predict Oxygen Desaturation in Smokers.

Anastasia K.A.L. Kwee, Wouter A.C. van Amsterdam, Firdaus A.A. Mohamed Hoesein, Leticia Gallardo-Estrella, Jean-Paul Charbonnier, Stephen M. Humphries, Harm A. W. M. Tiddens, James D. Crapo, Richard Casaburi, Pim A. de Jong and 2 more

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In one paragraph

Article in Chronic obstructive pulmonary diseases (Miami, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anastasia K.A.L. KweeDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
Wouter A.C. van AmsterdamDepartment of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
Firdaus A.A. Mohamed HoeseinDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
Leticia Gallardo-EstrellaThirona B.V., Nijmegen, The Netherlands
Jean-Paul CharbonnierThirona B.V., Nijmegen, The Netherlands
Stephen M. HumphriesDepartment of Radiology, National Jewish Health, Denver, Colorado, United States
Harm A. W. M. TiddensThirona B.V., Nijmegen, The Netherlands
James D. CrapoDepartment of Pulmonology, National Jewish Health, Denver, Colorado, United States
Richard CasaburiThe Lundquist Institute for Biomedical Innovation at Harbor, University of California Los Angeles Medical Center, Los Angeles, California, United States
Pim A. de JongDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
David A LynchDepartment of Radiology, National Jewish Health, Denver, Colorado, United States
Esther PompeDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897
6 · The paper itself

Abstract

Background and research question: Multiple factors affect oxygen levels in chronic obstructive pulmonary disease (COPD), including airflow limitation, emphysema, ventilation-perfusion mismatch, cardiac dysfunction, and pulmonary vascular remodeling. We investigated the association of small pulmonary vein and artery volume with oxygen saturation. Methods: In the COPD Genetic Epidemiology (COPDGene Results: A total of 8931 individuals were included with a mean age of 60.0±9.0 years. Of the participants, 52.7% were male. Half were current smokers (50.7%), and the number of pack years was 44.5±25.0. Median saturation was 97% (interquartile range 95%–98%), and 1040 (11.6%) participants used supplemental oxygen. Oxygen saturation decreased with 0.14% (-0.25, -0.03) ( Interpretation: In current and former smokers, higher small pulmonary vein and artery volume were associated with lower resting saturation and more supplemental oxygen use, independent of lung disease severity or technical parameters. This suggests a role for vascular remodeling in smoking-related disease.

Indexed as

chronic obstructive pulmonary diseaseoxygen saturationpulmonary vesselsquantitative computed tomography

Identifiers

PMID42007640
PMCPMC13382957

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.