Evidence map›Paper›PMID 42007539›Full record

ArticleBrain and behavior2026

A Single Dose of a Psychedelic Drug Repairs Prefrontal Cortex Synaptic Physiology in a Mouse Model of Prenatal Alcohol Exposure.

Tyler G Ekins, Tao Deng, Omar J Ahmed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tyler G EkinsDepartment of Psychology, University of Michigan, Ann Arbor, Michigan, USA.
Tao DengDepartment of Psychology, University of Michigan, Ann Arbor, Michigan, USA.
Omar J AhmedDepartment of Psychology, University of Michigan, Ann Arbor, Michigan, USA.

Funding

POSTDOCTORAL TRAINING IN THE BIOLOGY OF DRUG ABUSET32DA007268 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 1991 to 2021
$6.7M
Circuit Mechanisms of Psilocybin Following Chronic StressR01MH129282 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Omar Jamil Ahmed · 2022 to 2026
$1.9M
NIDA NIH HHS T32 DA007268NIDA NIH HHS T32DA007268NIH HHS R01MH129282NIH HHS T32DA007268NIMH NIH HHS R01 MH129282NIMH NIH HHS R01MH129282University of Michigan Eisenberg Family Depression Center Eisenberg Scholar Award
6 · The paper itself

Abstract

backgroundPrenatal alcohol exposure (PAE) can cause fetal alcohol spectrum disorders (FASDs), which are characterized by neural circuit and behavioral dysfunction due to impaired brain development. At the neural and behavioral levels, PAE is associated with disrupted cortical synaptic transmission and lifelong impairments in learning and cognitive control. Despite the prevalence of FASDs (affecting up to one in 20 school-aged children in the United States) and the associated personal, familial, and societal costs, there are currently no treatments to reverse neural circuit dysfunction.

methodsUsing whole-cell patch-clamp electrophysiology, we investigated intrinsic excitability and synaptic activity in prefrontal cortex (PFC) pyramidal neurons from adolescent mice prenatally exposed to ethanol (6.6%) and later given a single injection of either saline or 25CN-NBOH, a psychedelic neuroplastogen.

resultsWe found that PAE reduced intrinsic excitability and synaptic drive in PFC pyramidal neurons. 25CN-NBOH treatment partially rescued intrinsic excitability deficits and restored synaptic drive.

conclusionsPsychedelic neuroplastogens may show promise as potential therapeutics for synaptic deficits associated with PAE and should be further explored in preclinical models.

Indexed as

HallucinogensPrefrontal CortexPrenatal Exposure Delayed EffectsPyramidal CellsAnimalsDisease Models, AnimalEthanolFemaleFetal Alcohol Spectrum DisordersMaleMiceMice, Inbred C57BLNeuronal PlasticityPatch-Clamp TechniquesPregnancySynapsesEthanolHallucinogens25CN‐NBOHintrinsic electrophysiologypatch‐clampprenatal alcoholpsychedelicssynaptic electrophysiology

Identifiers

PMID42007539
PMCPMC13093898

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.