ArticleCNS neuroscience & therapeutics2026
Brain Alterations Linked to the MPTP Mouse Model of Parkinson's Disease Uncovered by Diffusion Kurtosis Imaging and Magnetic Resonance Spectroscopy.
Ajay Modi, Sheetal Maria, Jana Ruda-Kucerova, Eva Drazanova, Iveta Harastova-Pavlova, Alzbeta Sejnoha Minsterova, Kristina Kovacovicova, Daniel Havas, Irena Rektorova, Tiago F Outeiro and 1 more
Abstract read
In one paragraphArticle in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Ajay ModiCenter for Translational Medicine, International Clinical Research Centre, St. Anne's University Hospital Brno, Czech Republic.
Sheetal MariaCenter for Translational Medicine, International Clinical Research Centre, St. Anne's University Hospital Brno, Czech Republic.
Jana Ruda-KucerovaDepartment of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Eva DrazanovaDepartment of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Iveta Harastova-PavlovaInstitute of Scientific Instruments of the Czech Academy of Sciences, Brno, Czech Republic.
Kristina KovacovicovaPsychogenics Inc, Paramus, New Jersey, USA.
Daniel HavasPsychogenics Inc, Paramus, New Jersey, USA.
Tiago F OuteiroUniversity Medical Center Göttingen Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany.
Amit KhairnarCenter for Translational Medicine, International Clinical Research Centre, St. Anne's University Hospital Brno, Czech Republic.
Funding
European Union-Next Generation EU LX22NPO5107 (MEYS)Masaryk University as part of the project "Specific pharmacological research in pharmacokinetics, behavioural neuropsychopharmacology and personalised pharmacotherapy in oncology" MUNI/A/1722/2024Ministry of Education, Youth and Sports of the Czech Republic MUNI/A/1683/2024Ministry of Education, Youth and Sports of the Czech Republic (MEYS CR) LM2023050TFO DFG SFB1286TFO Project B8
6 · The paper itselfAbstract
aimsThis study employed diffusion kurtosis imaging (DKI) and proton magnetic resonance spectroscopy (
methodsMPTP (20 mg/kg, i.p.) was given for 4 days, and behavioral assessment, MRI imaging, and immunohistochemistry were performed at 24 h and 72 h after last MPTP treatment.
resultsAt 24 h, DKI showed higher diffusivity metrics in the hippocampus and thalamus, while
conclusionThese findings demonstrate DKI and
Indexed as
BrainDiffusion Tensor ImagingMPTP PoisoningParkinsonian DisordersAnimalsDiffusion Magnetic Resonance ImagingDisease Models, AnimalMaleMiceMice, Inbred C57BLProton Magnetic Resonance Spectroscopydiffusion kurtosis imaging (DKI)microstructural changesMPTP animal modelneurodegenerationParkinson's diseaseproton magnetic resonance spectroscopy (1H‐MRS)
Identifiers
PMID42007507
PMCPMC13093730
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390