Evidence map›Paper›PMID 42007476›Full record

ArticleTransboundary and emerging diseases2026

Chicken Infectious Anemia Virus Markedly Enhances the Pathogenicity of Infectious Bronchitis Virus-Infected Chickens.

Hao Chen, Shuangshuang Ma, Liuyang Yuan, Hongchun Yang, Shijun Xu, Shufeng Feng, Yaping Wang, Aobo Xu, Xiaoran Xuan, Ziqi Ling and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hao ChenCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.ORCID https://orcid.org/0009-0004-0124-4266
Shuangshuang MaCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.
Liuyang YuanCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.
Hongchun YangCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.
Shijun XuCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.
Shufeng FengCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.
Yaping WangCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.
Aobo XuCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.
Xiaoran XuanCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.
Ziqi LingCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.
Yang LiChina Animal Health and Epidemiology Center, Qingdao, 266032, China.
Hongbin SiCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.
Gonghe LiCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.ORCID https://orcid.org/0009-0003-0150-8818
Changbo OuCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, China, gxu.edu.cn.ORCID https://orcid.org/0000-0001-9912-5740

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chicken infectious anemia virus (CIAV) and infectious bronchitis virus (IBV) represent two of the most economically significant pathogens in the global poultry production. In recent years, coinfections involving CIAV and IBV have become increasingly prevalent in clinical scenarios across Southern China and globally. Nevertheless, the underlying synergistic pathogenic mechanisms remain largely elusive. This study establishes a coinfection model using specific pathogen-free (SPF) chickens infected with field-derived strains CIAV GDHY230813 and IBV CK/CK/GX/LA/071423 to systematically investigate pathogenic interactions. Our findings reveal a significant synergistic pathogenic effect through multiple experimental parameters between CIAV and IBV. Compared to the monoinfected controls, coinfected SPF chickens exhibited marked clinical deterioration: Survival rates decreased from 93.5% (CIAV) and 96% (IBV) to 76%, accompanied by profound growth retardation. In terms of viral transmission, coinfection markedly increased the viral shedding of both viruses through the respiratory and digestive tracts. At 14 days postinfection (dpi), the viral detection rates in both oropharyngeal and cloacal swabs soared to 100% in the coinfected group, up from 75% in the corresponding monoinfected groups. Moreover, coinfection facilitated the replication of IBV in the trachea, lungs, kidneys, and cecal tonsils. However, it did not lead to a significant change in the replication levels of CIAV. Pathological examinations revealed more severe lesions in the coinfected group, encompassing exacerbated atrophy of the thymus and bursa of Fabricius, splenomegaly, and heightened infiltration of inflammatory cells in various tissues. In summary, our findings suggest that coinfection with CIAV and IBV results in significant synergistic pathogenicity, worsening the severity of clinical disease and amplifying the potential for viral transmission. This study offers a vital theoretical foundation for comprehending the interactions between these two viruses and highlights the imperative of implementing integrated control strategies against both CIAV and IBV in chickens.

Indexed as

Chicken anemia virusChickensCircoviridae InfectionsCoinfectionCoronavirus InfectionsInfectious bronchitis virusPoultry DiseasesAnimalsSpecific Pathogen-Free OrganismsVirulencechicken infectious anemia virusco-infectionimmunosuppressioninfectious bronchitis viruspathogenicity

Identifiers

PMID42007476
PMCPMC13087508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.