Evidence map›Paper›PMID 42007445›Full record

ArticleHemaSphere2026

Improved red blood cell storage quality of blood from donors carrying the hypermorphic PIMT I120 variant.

Shaun Bevers, Aaron V Issaian, Ariel Hay, Gregory R Keele, Monika Dzieciatkowska, Julie A Reisz, Zachary B Haiman, Travis Nemkov, Daniel Stephenson, Amy L Moore and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Shaun BeversDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Aaron V IssaianDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Ariel HayUniversity of Virginia Charlottesville Virginia USA.
Gregory R KeeleRTI International Research Triangle Park North Carolina USA.
Monika DzieciatkowskaDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Julie A ReiszDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Zachary B HaimanDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Travis NemkovDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Daniel StephensonDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Amy L MooreRTI International Research Triangle Park North Carolina USA.
Xutao DengVitalant Research Institute San Francisco California USA.
Mars StoneVitalant Research Institute San Francisco California USA.
Kirk C HansenDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Steve KleinmanUniversity of British Columbia Vancouver British Columbia Canada.
Philip J NorrisVitalant Research Institute San Francisco California USA.
Michael P BuschVitalant Research Institute San Francisco California USA.
Bernhard O PalssonShu Chien-Gene Lay Department of Bioengineering University of California San Diego La Jolla California USA.
Nareg H RoubinianDepartment of Laboratory Medicine University of California San Francisco San Francisco California USA.
John JanetzkoDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Beat VӧgeliDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Grier P PageRTI International Research Triangle Park North Carolina USA.
David N JonesDepartment of Pharmacology University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Morkos A HenenDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Elan Z EisenmesserDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
James C ZimringUniversity of Virginia Charlottesville Virginia USA.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.ORCID https://orcid.org/0000-0002-2258-6490

Funding

REDS-IV-P - CENTER FOR TRANSFUSION LABORATORY STUDIES (CTLS) - SARS-CoV-2/COVID-19 STUDIES75N92019D00033 · NHLBI · VITALANT · PI NORRIS, PHILIP J. · 2019 to 2024
$15.6M
The Impact of Oxidative Stress on Erythocyte BiologyR01HL148151 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ALESSANDRO, ANGELO, KARAFIN, MATTHEW S · 2019 to 2022
$8.9M
The role of ferroptosis in red cell aging in vivo and in vitroR01HL146442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Angelo D'Alessandro, Adam N. Goldfarb · 2019 to 2026
$5.4M
The paradoxical response to iron in pulmonary hypertension of sickle cell diseaseR01HL161004 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUEHLER, PAUL WERNER, D'ALESSANDRO, ANGELO · 2022 to 2025
$2.7M
Interactions between the ADORA2b/Sphk1axis and the AE1-Hb switch in red blood cell aging in vivo and in vitroR01HL149714 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2023
$2.6M
The global regulation of dynamics and structure mediated by single hydride in a family of reductasesR01GM139892 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI EISENMESSER, ELAN Z · 2021 to 2024
$1.2M
NHLBI NIH HHS 75N92019D00033NHLBI NIH HHS R01 HL146442NHLBI NIH HHS R01 HL148151NHLBI NIH HHS R01 HL149714NHLBI NIH HHS R01 HL161004NIGMS NIH HHS R01 GM139892
6 · The paper itself

Abstract

Protein-l-isoaspartate

Identifiers

PMID42007445
PMCPMC13084699

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.