ArticleAging pathobiology and therapeutics2025
Endotoxin-induced acute lung injury in old C57BL/6J mice is a translationally relevant geroscience model.
Article in Aging pathobiology and therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinically important inflammatory lung conditions that contribute to substantial morbidity and mortality in humans, notably in the elderly population. Direct lung infection is a common cause of ALI and can be modeled by experimental administration of lipopolysaccharide (LPS) bacterial endotoxin. Acute pulmonary pathology observations are presented using an intratracheal LPS-induced ALI experimental model in aged C57BL/6J mice. Collectively the histopathologic findings in LPS treated mice demonstrate several key characteristic features of ALI, supporting the translational relevance of this model for investigating the pathogenesis of lung injury in older adults.
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