Evidence map›Paper›PMID 42007368›Full record

ArticleTechnical innovations & patient support in radiation oncology2026

Towards a shuttle-based workflow for daily online magnetic resonance imaging-guided particle therapy: Anatomical robustness and organ variability in the female pelvis.

Friderike K Longarino, Danae Droutsas, Lars Wessel, Cedric Beyer, Rita Pestana, Julia Bauer, Katharina Seidensaal, Jürgen Debus, Sebastian Klüter, Nathalie Arians

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Article in Technical innovations & patient support in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Friderike K LongarinoClinical Cooperation Unit Translational Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Danae DroutsasDepartment of Radiation Oncology and Heidelberg Ion Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg, Germany.
Lars WesselDepartment of Radiation Oncology and Heidelberg Ion Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg, Germany.
Cedric BeyerDepartment of Radiation Oncology and Heidelberg Ion Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg, Germany.
Rita PestanaDepartment of Radiation Oncology and Heidelberg Ion Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg, Germany.
Julia BauerDepartment of Radiation Oncology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Katharina SeidensaalDepartment of Radiation Oncology and Heidelberg Ion Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg, Germany.
Jürgen DebusDepartment of Radiation Oncology and Heidelberg Ion Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg, Germany.
Sebastian KlüterDepartment of Radiation Oncology and Heidelberg Ion Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg, Germany.
Nathalie AriansDepartment of Radiation Oncology and Heidelberg Ion Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Purpose: Online adaptive particle therapy can take into account anatomical changes during the course of treatment. In a shuttle-based daily online magnetic resonance imaging (MRI)-guided strategy, patients remain immobilized in the treatment position during transfer between MRI and irradiation. This study investigated positional stability and organ variability in the female pelvic region during shuttle transfers. Material and Methods: Twenty healthy female volunteers underwent four MRI scans (B Results: Median DSC (MDA) of the external was 0.99 (0.5 mm) for MRI 1-2, 0.99 (0.9 mm) for MRI 2-3, and 0.99 (0.9 mm) for MRI 3-4. Median MDA values observed for MRI 1-2/MRI 2-3/MRI 3-4 were 2.2/2.8/1.8 mm (cervix), 3.4/3.7/3.6 mm (uterus), 3.6/4.2/3.7 mm (bladder), 2.0/2.3/2.3 mm (intestine), and 1.6/1.4/1.7 mm (rectum). Statistically significant Pearson correlations were found between DSC/MDA values of gynecological structures and bladder volume differences. Conclusions: High stability in the external outline of the female pelvis can be maintained in a shuttle-based workflow for MRI-guided adaptive particle therapy. Physiological organ motion remained the main source of variability and was only marginally influenced by the shuttle transport.

Indexed as

Cervical cancerDaily online adaptive radiotherapyFemale pelvisMRI-guided particle therapyShuttle transfer

Identifiers

PMID42007368
PMCPMC13091318

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