Evidence map›Paper›PMID 42007246›Full record

ArticleNeurosurgery practice2026

Patient's Age Impact on Stroke Risk and Intracranial Aneurysm Occlusion: SCENT Flow Diverter Study-A Nonrandomized Clinical Trial on Large and Giant Aneurysms.

Ajay K Wakhloo, Paul Jenkins, Philip M Meyers, Alexander L Coon, Peter T Kan, Ajit S Puri, Joost de Vries, Giuseppe Lanzino, Mark D Bain, Koji C Ebersole and 8 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01716117 (The Surpass Intracranial Aneurysm Embolization System Pivotal Trial to Treat Large or Giant Wide Neck Aneurysms), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01716117 nacompletednot on this map

The Surpass Intracranial Aneurysm Embolization System Pivotal Trial to Treat Large or Giant Wide Neck Aneurysms (SCENT Trial)

TypeinterventionalSponsorStryker NeurovascularRan2012 to 2022Enrolled213ConditionsBrain AneurysmArmsSurpass Flow Diverter
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ajay K WakhlooDepartment of Radiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Paul JenkinsStatistical Consultant, Stryker Neurovascular, Fremont, California, USA.
Philip M MeyersDepartment of Radiology, Columbia University, New York, New York, USA.
Alexander L CoonCarondelet Neurosurgical Institute of St. Joseph's Hospital, Tucson, Arizona, USA.
Peter T KanDepartment of Neurosurgery, University of Texas Medical Center, Galveston, Texas, USA.
Ajit S PuriDivision of Neurointerventional Radiology, UMASS Chen School of Medicine, Worcester, Massachusetts, USA.
Joost de VriesDepartment of Neurosurgery, Radboud, University of Nijmegen, Nijmegen, The Netherlands.
Giuseppe LanzinoDepartment of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA.
Mark D BainDepartment of Neurosurgery, Cerebrovascular Center Cleveland Clinic, Cleveland, Ohio, USA.
Koji C EbersoleDepartment of Neurosurgery, University of Kansas Health Systems, Kansas City, Kansas, USA.
Babu G WelchDepartment of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Aclan DoganDepartment of Neurosurgery, Oregon Health & Science University, Portland, Oregon, USA.
Pascal M JabbourDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
J MoccoDepartment of Neurosurgery, Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center, New York, New York, USA.
Adnan H SiddiquiDepartment of Neurosurgery, SUNY University at Buffalo, Buffalo, New York, USA.
Aquilla S TurkDepartment of Neuroendovascular Surgery, University of South Carolina School of Medicine - Greenville, Greenville, South Carolina, USA.
Philipp TausskyDepartment of Neurosurgery, Beth Israel Deaconess Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ricardo A HanelLyerly Neurosurgery, Jacksonville, Florida, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe prospective single-arm nonrandomized SCENT (Surpass Intracranial Aneurysm Embolization System Pivotal) trial on flow diverter treatment of large and giant intracranial aneurysms (IA) was analyzed for patients' age and IA characteristics affecting stroke and occlusion rates over 5 years (Trial registration NCT01716117).

methodsImpact on major ipsilateral stroke and IA occlusion was studied by stratifying age as 65 years and younger vs older than 65. Kaplan-Meier estimates of time to both endpoints, stratified by age, were created. Univariate predictors of time-to-stroke were analyzed using univariable proportional hazards regression models. Limited bivariable modeling was also attempted.

resultsOf 180 patients with large or giant IA enrolled, 119 were 65 years and younger, whereas 61 were older than 65 years. The 3-year risk of stroke for the older than 65 years group (19.7%) was more than double that of the 65 years and younger group (9.2%),

conclusionAge older than 65 was associated with an increased risk of stroke and predictive of incomplete healing and increased time to healing.

Indexed as

AgeAneurysmsBrainEndovascularFlow diverterStroke risk

Identifiers

PMID42007246
PMCPMC13086414

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.