Evidence map›Paper›PMID 42007240›Full record

ArticleJournal of ophthalmology2026

Monitoring Systemic Inflammatory Indices and Retinal Changes Over Time Following Initial Diagnosis of Diabetic Retinopathy.

Emre Aydın, Şaban Kılıç, Çiğdem Deniz Genç

Erratum issuedAbstract read
In one paragraph

Article in Journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Emre AydınDepartment of Ophthalmology, Samsun Education and Research Hospital, Samsun, Turkey.ORCID https://orcid.org/0000-0002-1895-8538
Şaban KılıçDepartment of Ophthalmology, Samsun Training and Research Hospital, Samsun, Turkey, samsundh.gov.tr.ORCID https://orcid.org/0000-0002-1077-0581
Çiğdem Deniz GençDepartment of Ophthalmology, Samsun Education and Research Hospital, Samsun, Turkey.ORCID https://orcid.org/0000-0001-5287-4074

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to evaluate changes in systemic inflammatory indices and retinal structural parameters in newly diagnosed diabetic retinopathy (DR) patients before and after intravitreal anti-VEGF treatment. Material and Methods: A total of 308 participants (157 DR patients and 151 healthy controls) were enrolled. Systemic inflammatory status was assessed using hematologic indices derived from routine complete blood count parameters. Optical coherence tomography (OCT) was used to measure macular thickness. DR patients were evaluated at three time points: before treatment, 1 month, and 3 months after anti-VEGF injection. Results: Baseline inflammatory indices (NLR, MLR, PLR, and SII) and macular thickness were significantly higher in the DR group compared to controls ( Conclusion: Systemic inflammatory activity is closely associated with both the onset and progression of DR. The evaluation of inflammatory indices such as NLR and SII together with OCT findings may support diagnosis and treatment follow-up in clinical practice.

Indexed as

diabetic retinopathyNLRoptical coherence tomographySIIsystemic inflammation

Identifiers

PMID42007240
PMCPMC13085114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.