ReviewJournal of the National Cancer Center2026
The role of circadian disruption, sleep dysregulation, lifestyle factors, and metabolic reprogramming in the pathogenesis and progression of ovarian cancer.
Review in Journal of the National Cancer Center, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Work at night, sleep loss, fatigue, and cancer: exposure, mechanisms, and epidemiological evidence.Journal of the National Cancer Center · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ovarian cancer remains one of the most lethal gynecologic malignancies, with high mortality due to late-stage diagnosis and limited effective treatments. Recent evidence highlights the importance of circadian rhythms, metabolic reprogramming, and lifestyle factors in shaping the initiation, progression, and treatment response of ovarian tumors. Disruption of the circadian clock, via genetic dysregulation or lifestyle behaviors such as night-shift work and poor sleep, has been associated with tumorigenesis, metabolic imbalance, and chemoresistance. Additionally, ovarian cancer cells demonstrate distinct metabolic adaptations, including enhanced glycolysis and glutaminolysis, supporting rapid proliferation and survival. Lifestyle factors such as diet, physical inactivity, obesity, and psychosocial stress further modulate cancer risk and therapeutic outcomes. This review synthesizes evidence on the molecular underpinnings of circadian and metabolic disruption in ovarian cancer and their interaction with modifiable behavioral factors. Furthermore, it explores emerging strategies such as chronotherapy and metabolic targeting to improve treatment efficacy and survivorship. The goal is to encourage a multidimensional perspective that integrates molecular biology with lifestyle medicine in the management of ovarian cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.