Evidence map›Paper›PMID 42007186›Full record

ArticleCJC open2026

Cerebral Hemodynamics Are Related to Cortical Brain Morphology in Heart Failure with Reduced Ejection Fraction Independent of Reduced Cardiac Output.

Cameron J Morse, Adam M S Luchkanych, Natasha G Boyes, Allen A Champagne, Michael D Nelson, Geoffrey Karjala, Alexander Zhai, Haissam Haddad, Darcy D Marciniuk, Michael E Kelly and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CJC open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cameron J MorseDepartment of Biomedical Sciences, Western College of Veterinary Medicine, The University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Adam M S LuchkanychDepartment of Biomedical Sciences, Western College of Veterinary Medicine, The University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Natasha G BoyesCollege of Kinesiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Allen A ChampagneSchool of Medicine, Queen's University, Kingston, Ontario, Canada.
Michael D NelsonDepartment of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA.
Geoffrey KarjalaCollege of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Alexander ZhaiCollege of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Haissam HaddadCollege of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Darcy D MarciniukCollege of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Michael E KellyCollege of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Corey R TomczakCollege of Kinesiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
T Dylan OlverDepartment of Biomedical Sciences, Western College of Veterinary Medicine, The University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate whether reduced cerebral blood flow is associated with cortical brain remodelling in patients with heart failure with reduced ejection fraction (HFrEF). Further, to assess whether these changes occur independently of decreased cardiac output and correlate with alternative markers of HFrEF severity. The findings suggest that brain remodelling in HFrEF can occur independently of reduced cardiac output, highlighting the importance of other pathophysiological factors. A nuanced understanding of these mechanisms could inform improved diagnostic and therapeutic strategies targeting cardiocerebral interactions.

Indexed as

cerebralcortical thicknessheart-brainheart failurehemodynamics

Identifiers

PMID42007186
PMCPMC13084288

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.