Evidence map›Paper›PMID 42007185›Full record

ArticleCJC open2026

Understanding the Nature and Impact of Chest Pain in Postural Orthostatic Tachycardia Syndrome.

Kavithra Karalasingham, Mishal Fayyaz, Robert S Sheldon, Kathryn King-Shier, Satish R Raj

Abstract read
In one paragraph

Article in CJC open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kavithra KaralasinghamDepartment of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada.
Mishal FayyazDepartment of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada.
Robert S SheldonDepartment of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada.
Kathryn King-ShierLibin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada.
Satish R RajDepartment of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postural orthostatic tachycardia syndrome (POTS) is a chronic autonomic disorder that predominantly affects female patients of childbearing age. Chest pain is a common and debilitating symptom in POTS, but the nature of the chest pain and the patient experience surrounding it remain poorly understood. Methods: A qualitative descriptive design was used. Sixteen patients diagnosed with POTS who were experiencing chest pain were recruited. Semistructured video interviews were conducted that explored the nature and impact of chest pain in daily life. Transcribed interviews were manually analyzed using conventional content analysis. Results: Most patients described their chest pain as sharp and stabbing, often radiating from the left side of the chest to the jaw, back, or arms. Triggers for chest pain included physical exertion, such as walking and using stairs, and high temperatures; few described the pain as unpredictable. Frequency and duration of pain varied widely across patients, with episodes of pain ranging from fleeting to constant. Many shared that chest pain restricted physical activities that they once engaged in with their peers and that their social lives were directly affected, as shortness of breath from talking could trigger chest pain. Many patients also described feelings of isolation and frustration because of both their limited social and physical activities and recognition of a decrease in their overall capabilities. The most common coping strategies to mitigate chest pain were sitting or lying down and breathing strategies. Conclusions: Chest pain in POTS affects multiple dimensions of patients' lives and requires ongoing adaptation and coping.

Indexed as

chest painpostural orthostatic tachycardia syndromequality of life

Identifiers

PMID42007185
PMCPMC13084243

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.