ArticleAmerican journal of translational research2026
Aquaporin-1 upregulation is associated with scleral remodeling during myopia development in mice.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo determine the functional importance of aquaporin-1 (Aqp1) in scleral remodeling during myopia development using
methodsForty-two C57BL/6J mice were randomly assigned into experimental (n=28) and normal control (NC) groups (n=14). In the experimental group, the right eyes underwent form deprivation (deprived eye, DE), whereas the left eyes served as self-controls (fellow eye, FE). Mice in the normal control (NC) group received no treatment in either eye. Refraction was measured before and after myopia induction, and axial length was measured at the end of the experiment. The expression levels of Aqp1, hypoxia-inducible factor-1 alpha (Hif-1α), matrix metallopeptidase 9 (Mmp9), and collagen type I alpha1 (Col1α1) in sclera were determined by immunofluorescence staining, qRT-PCR, and/or western blotting. Scleral morphology was evaluated using hematoxylin and eosin staining.
resultsAfter two weeks of form-deprivation, DE eyes exhibited a significant myopic shift (1.66±0.09 D) compared with FE eyes (4.92±0.06 D) and NC eyes (left: 4.78±0.11 D; right: 4.91±0.10 D). Scleral thinning was found in DE eyes. Expression levels of Aqp1, HIF-1α, and Mmp9 were significantly upregulated, whereas Col1α1 expression level was significantly downregulated in DE eyes compared to FE and NC eyes.
conclusionsThe findings indicated that Aqp1 upregulation was associated with scleral remodeling during myopia development and Aqp1 could contribute to this process, at least in part, through regulation of Mmp9 expression level.
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