ArticleAmerican journal of translational research2026
Evaluation of continuous axial stress on tibial fracture healing in canine models using custom external fixator.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the effects of physiologically relevant continuous axial stress on tibial fracture healing in canines using a custom external fixator.
methodsA custom external fixator was developed to apply quantifiable stress. First, maximum axial stress derived from muscle contraction was measured using a film sensor. Subsequently, canine tibial fracture models were established and assigned to non-stress, half-maximum stress, or maximum stress groups. Healing was evaluated via radiography, micro-computed tomography (Micro-CT), biomechanical testing, Western Blot, and Real-time Polymerase Chain Reaction (PCR).
resultsThe maximum physiological axial stress was measured at 460 g. Compared with maximum stress and non-stress groups, the half-maximum stress group exhibited superior fracture healing, evidenced by increased callus formation and bone volume ratio (BV/TV) in X-ray and micro-CT analyses. Biomechanical testing demonstrated significantly higher ultimate strength in the half-maximum group. Molecular analyses further supported these observations, showing sustained upregulation of Runt-related transcription factor 2 (RUNX2) and Type I Collagen (COL-1) expression in the half-maximum group.
conclusionsMuscle contraction generates a maximum axial stress of approximately 460 g at canine tibial fracture sites. Continuous application of half the maximum axial stress significantly enhances fracture healing compared to both maximum stress and non-stress conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.