ArticleAmerican journal of translational research2026
Clinical characteristics and factors associated with dentition defects in patients with diabetes mellitus and concomitant endodontic disease.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study focused on patients with endodontic disease (ED) and diabetes mellitus (DM), and analyzed the predisposing factors of dental defects, so as to provide a new reference for the management of dental complications in DM-related oral patients.
methodsIn this regression analysis, we included 178 ED patients admitted to Shanghai Xuhui District Stomatological Hospital from January 2022 to June 2024, including 54 with ED alone (ED group) and 124 with ED concurrent with DM (ED+DM group). We collected the clinical data and laboratory indexes, periodontal indices, endodontic disease characteristics and laboratory findings (glycated hemoglobin [HbA1c], fasting plasma glucose [FPG]). We compared the differences in data between the DM group and ED+DM group, and further logistic regression analysis was used for the indicators with differences.
resultsFirst, by univariate analysis, we found that compared with the ED group, the DM+ED group reported less intense spontaneous and nocturnal pain (P<0.05) but experienced prolonged pain from thermal stimuli (P<0.05). In addition, ED+DM patients also had a higher prevalence of root canal calcification and higher postoperative VAS score. (P<0.05). Independent risk factors for dentition defects identified through multivariate analysis were HbA1c, FPG, diabetes duration, and probing depth (PD) ≥4 mm (P<0.05).
conclusionPoor blood glucose control, progression of periodontal inflammation, and different types of diabetes were independent influencing factors for dentition defects in the DM+ED group.
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