ArticleAmerican journal of translational research2026
Comparison of short- and long-term efficacy between percutaneous and open pedicle screw fixation for thoracolumbar vertebral fracture.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo compare the short-term and long-term efficacy of percutaneous pedicle screw fixation (PPSF) and open pedicle screw fixation (OPSF) in treating thoracolumbar vertebral fracture (TVF).
methodsWe performed a retrospective cohort analysis of 158 patients with TVF. Patients were categorized into PPSF (n = 86) and OPSF (n = 72) groups based on the surgical procedure. Perioperative parameters, wound healing, functional outcomes (Visual Analogue Scale [VAS] and Oswestry Disability Index [ODI]), radiological parameters (percentage of anterior vertebral body height [PAVBH] and Cobb angle), and complications were collected at 7 days, 6 months, and 12 months postoperatively. Statistical analysis included independent t-tests, repeated measures ANOVA for longitudinal data, and multivariate linear regression analysis to identify independent predictors of long-term outcomes.
resultsThe PPSF group demonstrated superior perioperative outcomes, including shorter operative time (P = 0.008), less blood loss, shorter hospital stay, and faster wound healing (all P < 0.001). Repeated-measures ANOVA revealed significant group-by-time interactions for VAS, ODI, PAVBH, and Cobb angle (all P < 0.01). The PPSF group consistently showed better pain control and functional recovery from 6 months onwards, and superior early radiological correction. During the 12-month follow-up, despite radiological outcomes were comparable, the PPSF group maintained significantly lower VAS and ODI scores (both P < 0.001). Multivariate regression analysis confirmed PPSF as an independent factor associated with better 12-month ODI (β = -5.19, P < 0.001) and VAS scores (β = -0.56, P < 0.001). The overall complication rate was significantly lower in the PPSF group (P = 0.028).
conclusionPPSF can reduce surgical trauma, promote faster recovery, and improve functional outcomes in patients with TVF, suggesting it as a promising alternative to OPSF. Further studies are needed to confirm these findings and assess long-term efficacy.
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