ReviewAmerican journal of translational research2026
Exosomes: critical mediator and therapeutic target for osteoarthritis.
Review in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
9 authors.
Funding
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Abstract
Osteoarthritis (OA) is characterized by articular cartilage degradation and chondrocyte injury. Increased cell apoptosis of chondrocytes and inflammation are features of degenerating cartilage. Recently, exosomes are considered as important mediators of the pathogenesis and progression of OA. Importantly, exosomes originating from different cells, especially mesenchymal stem cells (MSC), have been shown to delay the progression of OA by different mechanisms. These exosomes derived from MSC harbor several proteins, lipids, nucleic acids, and cytosolic material that promote chondrocyte proliferation and migration and prevent the apoptosis of chondrocytes. Based on these findings, exosomes may serve be diagnostic biomarkers and therapeutic targets for OA. In this review, we summarize the role of exosomes and their key components in mediating OA development and therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.