ArticleAmerican journal of translational research2026
Early initiation of continuous renal replacement therapy improves outcome in sepsis-associated acute kidney injury.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the effect of initiation timing of Continuous Renal Replacement Therapy (CRRT) on prognosis in Sepsis-Associated Acute Kidney Injury (SAKI).
methodsA total of 113 SAKI patients receiving CRRT were stratified by initiation timing: early-stage (ES, ≤ 12 h; n = 51), intermediate-stage (IS, 12-24 h; n = 35), and advanced-stage (AS, > 24 h; n = 27). Organ function (SOFA score), inflammatory markers (C-reactive protein, CRP; procalcitonin, PCT), renal function (serum creatinine, SCr), clinical course (ICU stay, mechanical ventilation, CRRT duration), and 90-day survival were compared.
resultsThe AS Group showed the most severe multi-organ dysfunction at day 3, with higher SOFA scores (12 vs. 8 in ES, P = 0.037), BNP (809 vs. 361 pg/mL, P < 0.001), and INR (2.21 vs. 1.53, P < 0.001). Inflammation markers were also highest in AS (CRP: 92.81 mg/L; PCT: 4.25 ng/mL; P = 0.009 and P = 0.002). By day 5, SCr was significantly higher in AS (165.77 μmol/L) than ES (127.17 μmol/L, P = 0.004). The AS Group had longer ICU stays (12.5 d vs. 9.5 d, P = 0.031) and mechanical ventilation (8.5 vs. 5.5 d,
conclusionEarly CRRT (≤ 12 h) improved organ function, enhanced inflammatory control, and reduced mortality risk, while delayed initiation (> 24 h) correlated with worse outcome.
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