Evidence map›Paper›PMID 42007058›Full record

ArticleACS measurement science au2026

Dissolved Oxygen-Dependent Magnetophoresis of Sickle Red Blood Cells and Proof-of-Concept Separation Using a Magnetic Column.

Jacob Strayer, Poornima Ramesh Iyer, Xian Wu, Hyeon Choe, Md Majidur Rahman, Jacob Doon-Ralls, Jenifer Gómez-Pastora, Kristina Landes, Payal C Desai, Sherraine Della-Moretta and 3 more

Abstract read
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In one paragraph

Article in ACS measurement science au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jacob StrayerWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.
Poornima Ramesh IyerWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.ORCID https://orcid.org/0009-0009-0527-6202
Xian WuWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.ORCID https://orcid.org/0000-0001-6379-5750
Hyeon ChoeWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.
Md Majidur RahmanWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.
Jacob Doon-RallsWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.
Jenifer Gómez-PastoraDepartment of Chemical Engineering, Texas Tech University, Lubbock, Texas 79409, United States.
Kristina LandesBenign Hematology Team, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43203, United States.
Payal C DesaiSickle Cell Enterprise, Levine Cancer Institute, Atrium Health, Charlotte, North Carolina 28204, United States.
Sherraine Della-MorettaBenign Hematology Team, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43203, United States.
Andre F PalmerWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.
Maciej ZborowskiDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44106, United States.
Jeffrey J ChalmersWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.ORCID https://orcid.org/0000-0003-1723-9774

Funding

Fractionation of Aged RBCs Based on Hemoglobin ContentR01HL131720 · NHLBI · OHIO STATE UNIVERSITY · PI CHALMERS, JEFFREY JOHN, PALMER, ANDRE FRANCIS · 2017 to 2020
$2.7M
Fractionation of RBCs via label-free magnetophoresis using novel additive-manufactured devicesR15HL181720 · NHLBI · TEXAS TECH UNIVERSITY · PI GOMEZ PASTORA, JENIFER · 2025 to 2025
$588k
Development of single cell magnetophoresis to analyze and isolate glioma cancer stem cellsR21CA250118 · NCI · OHIO STATE UNIVERSITY · PI CHALMERS, JEFFREY JOHN, VENERE, MONICA · 2020 to 2021
$385k
Sickle cell disease severity prediction from the magnetic signature and hemoglobin content of blood cellsR03AI188351 · NIAID · TEXAS TECH UNIVERSITY · PI GOMEZ PASTORA, JENIFER · 2025 to 2025
$150k
NCI NIH HHS R21 CA250118NHLBI NIH HHS R01 HL131720NHLBI NIH HHS R15 HL181720NIAID NIH HHS R03 AI188351
6 · The paper itself

Abstract

Red blood cell (RBC) function is significantly altered in sickle cell disease (SCD) due to the polymerization of sickle hemoglobin (HbS) into polymers under deoxygenated conditions leading to the formation of sickle shaped RBCs. Since magnetophoretic mobility is inversely proportional to hemoglobin (Hb) oxygen saturation, we investigated whether magnetophoresis could distinguish RBCs from healthy donors and those from sickle cell patients. Single-cell magnetophoretic mobilities were measured for 4 healthy and 5 SCD samples using cell tracking velocimetry (CTV) under controlled partial pressures of oxygen (pO

Indexed as

cell tracking velocimetrymagnetic separationpacked columnred blood cellssickle cell disease

Identifiers

PMID42007058
PMCPMC13087947

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.