Trial reportOsteoarthritis and cartilage open2026
The effects of supervised exercise and pain neuroscience education on muscle strength and power in patients with chronic pain after total knee arthroplasty: An exploratory analysis from the NEPNEP trial.
Trial report in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03886259 (Effect of Neuromuscular Exercise in Combination With Pain Neuroscience Education Compared to Pain Neuroscience Education Alone in Patients With Chronic Pain After Primary Total Knee Arthroplasty), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Neuromuscular Exercise in Combination With Pain Neuroscience Education Compared to Pain Neuroscience Education Alone in Patients With Chronic Pain After Primary Total Knee Arthroplasty: A Randomized Controlled Trial
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study investigated the effects of neuromuscular exercises and pain neuroscience education (PNE) compared with PNE alone on muscle strength and power in patients with chronic pain after total knee arthroplasty (TKA). Design: Secondary analysis of a randomized controlled trial. Patients with chronic pain for >1-year after TKA were randomized to supervised neuromuscular exercises with PNE or PNE alone. The neuromuscular exercise group underwent 24 sessions over 12-weeks. The PNE was delivered in two 1-h group sessions, identical in the two groups. Outcomes included maximum voluntary isometric contractions for knee extensors and flexors, peak leg extension power and the Knee injury and Osteoarthritis Outcome Score (KOOS). Outcomes were measured at baseline, 3, 6, and 12-months. Analysis was conducted using repeated measures mixed models. Multivariable linear regression, with groups collapsed into one, was conducted to evaluate associations. Results: Sixty-nine participants were enrolled, 36 in the exercise and PNE group and 33 in the PNE alone group. No significant between-group differences were found in changes from baseline to 12-months for muscle strength or leg extension power. The exercise and PNE group showed significant within-group improvements in leg extension power (26.3 W, Conclusions: Neuromuscular exercises and PNE do not seem to provide superior improvements in muscle strength or power compared to PNE alone in patients with chronic pain after TKA. Trial registry: The trial was pre-registered at ClinicalTrials.gov (NCT03886259).
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