Articlenpj veterinary sciences2026
Experimental infection and viral pathogenesis of a human isolate of H5N1 highly pathogenic avian influenza strain in Jersey cows.
Article in npj veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Bovine mammary tissues are susceptible to infection by viruses bearing panzootic H5N1 influenza A virus glycoproteins.The Journal of general virology · 2026Article
- Surveillance on California dairy farms reveals multiple possible sources of H5N1 influenza virus transmission.PLoS biology · 2026Article
- Pathogenesis of H5N1 Clade 2.3.4.4b in dry Jersey cows following intramammary inoculation shows within-host compartmentalization.bioRxiv : the preprint server for biology · 2026Article
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Highly pathogenic avian influenza H5N1 viruses have circulated globally since 1996. In recent years, clade 2.3.4.4b H5N1 viruses have crossed the species barrier into multiple species, including dairy cattle. Previous studies have demonstrated that Holstein cows are susceptible to H5N1 infection. To investigate whether Jersey cows are susceptible to H5N1 infection, we inoculated three Jersey lactating cows intranasally and intramammarily with a human H5N1 influenza virus. Following inoculation, milk production rapidly decreased, and milk samples exhibited a colostrum-like appearance. Milk production remained low for at least seven days. Infection was confirmed by high levels of viral RNA detected in external and internal swabs of infected teats and milk samples. Conversely, low levels of viral RNA were detected in the respiratory tract of infected cows. These findings confirm that Jersey cows are susceptible to H5N1 infection and establish them as a valuable experimental model for studying disease pathogenesis and vaccine development.
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