ReviewJGH open : an open access journal of gastroenterology and hepatology2026
Timing of Cholecystectomy After Acute Biliary Severe Pancreatitis: A Systematic Review-Time for A Clinical Trial?
Review in JGH open : an open access journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There is a lack of evidence about the optimal timing for cholecystectomy in patients with severe acute pancreatitis. The discussion centers on evaluating the benefits of performing early versus delayed cholecystectomy, looking for better outcomes. This systematic review aimed to assess the postoperative outcomes after cholecystectomy in patients with severe pancreatitis regarding the timing of the surgery. Methods: A systematic review was conducted, and the inclusion criteria included original, peer-reviewed retrospective or prospective studies involving humans > 18 years old with acute severe pancreatitis due to gallstone disease who underwent laparoscopic cholecystectomy. Newcastle Ottawa score was used to perform quality and bias assessment. The search was conducted from January 2004 to December 2023 within Pubmed, EMBASE, and Scopus. Results: A total of 1198 studies were found; after screening for duplicates, eligibility criteria and conducting quality assessment, three articles met the inclusion criteria and were included in the systematic review, involving a total of 598 patients. Early cholecystectomy (Defined < 15 days or 6 weeks) was performed in 30.10% ( Conclusion: Despite limitations regarding the small sample size and the small amount of research published to date, this systematic review suggests that there is a higher risk of morbidity and mortality in patients with severe pancreatitis undergoing early cholecystectomy compared to those undergoing delayed cholecystectomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.