Regulation of P450-derived epoxy fatty acids in cardiovascular diseases.

Matthew L Edin, Joan P Graves, Darryl C Zeldin

Abstract read

In one paragraph

Article in Redox biochemistry and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matthew L EdinDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA.ORCID 0000-0002-7042-500X

Joan P GravesDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA.

Darryl C ZeldinDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA.

Funding

P450 Arachidonate EpoxygenasesZ01ES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 1995 to 2008

$2.2M

Intramural NIH HHS Z01 ES025034Intramural NIH HHS Z99 ES999999

6 · The paper itself

Abstract

The cytochrome P450 (P450 or CYP) superfamily, while extensively recognized for xenobiotic metabolism, is also critically involved in the biosynthesis of lipid mediators from polyunsaturated fatty acids (PUFAs). Distinct from cyclooxygenase (COX) and lipoxygenase (LOX) pathways, P450 enzymes uniquely catalyze the metabolism of PUFAs such as arachidonic acid (AA), to epoxy fatty acids (EpFAs), such as epoxyeicosatrienoic acids (EETs) and mid-chain or ω-terminal hydroxyeicosatrienoic acids (HETEs). Eicosanoid biosynthesis is initiated by phospholipase A

Indexed as

CardiovascularCytochrome P450EicosanoidsLipid oxidationOxylipins

Identifiers

PMID42006847

DOI10.1016/j.rbc.2025.100064

PMCPMC13089904

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.