Evidence map›Paper›PMID 42006844›Full record

ArticleClinical and experimental gastroenterology2026

The Role of Nuclear APOBEC Enzymes in Neoplastic Progression of Ulcerative Colitis.

Lene Alsøe, Stephan Andreas Brackmann, Yan Liu, Anna Berit Wennerström, Qin Ying Esbensen, Sumana Kalyanasundaram, Yohan Lefol, Diana Domanska, Solveig Norheim Andersen, Hilde Loge Nilsen

Abstract read
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In one paragraph

Article in Clinical and experimental gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lene Alsøe *Department of Microbiology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-8711-8479
Stephan Andreas Brackmann *Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0001-6434-0571
Yan LiuDepartment of Clinical Molecular Biology, Akershus University Hospital, Lørenskog, Norway.
Anna Berit WennerströmDepartment of Clinical Molecular Biology, Akershus University Hospital, Lørenskog, Norway.ORCID 0000-0001-8143-9944
Qin Ying EsbensenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Sumana KalyanasundaramDepartment of Informatics, University of Oslo, Oslo, Norway.
Yohan LefolInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Diana DomanskaInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Solveig Norheim AndersenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Hilde Loge NilsenDepartment of Microbiology, Oslo University Hospital, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant expression of the cytidine DNA deaminase AID in enterocytes within inflamed mucosa in ulcerative colitis (UC) patients has been proposed to be involved in progression of UC to colitis-associated colorectal cancer (CA-CRC). Here, we followed the expression of AID and other nuclear cytidine DNA deaminases of the APOBEC family through several stages of progression of UC in a CA-CRC case (UC progressor) and in a cohort of UC progressors and non-progressors. In inflamed and high-grade dysplastic mucosa,

Indexed as

AIDcolorectal cancerDNA damage responsegenome instabilityinflammatory bowel disease

Identifiers

PMID42006844
PMCPMC13089235

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.