ArticlemedRxiv : the preprint server for health sciences2026
MyGeneRisk Colon: A Web-Based Tool for Personalized Colorectal Cancer Risk Prediction Based on Genetics and Lifestyle.
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Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
44 authors.
Jiayin ZhengDepartment of Biostatistics, Epidemiology, and Informatics at the University of Pennsylvania Perelman School of Medicinev.ORCID 0000-0002-5559-6847
Robert S SteinfelderPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Hang YinPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Conghui QuPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Minta ThomasPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Sushma S ThomasPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Cynthia AndrewsNorth Sound Accountable Communities of Health, Bellingham Washington, USA.
Bianca AugustoDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, USA.
Douglas C CorleyDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Jeffrey K LeeDepartment of Gastroenterology, Kaiser Permanente San Francisco Medical Center, San Francisco, California, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Chris GignouxColorado Center for Personalized Medicine, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, USA.
Shauna R GoldbergKaiser Permanente Colorado Institute for Health Research, Aurora, Colorado, USA.
Christopher A HaimanCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jeroen R HuyghePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Motoki IwasakiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
Loic Le MarchandPopulation Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Soo Chin LeeNational University Cancer Institute, Singapore, Singapore.
Johana MelendezHillsborough College, Plant City, Fl. USA.
Ivan MesaHillsborough College, Tampa, FL, USA.
Shuji OginoProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Viviam SifontesMoffitt Cancer Center, Tampa, FL, USA.
Caroline Y UmDepartment of Population Science, American Cancer Society, Atlanta, Georgia.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA and Department of Oncology, Johns Hopkins Kimmel Cancer Center, Baltimore Maryland, USA.
Larissa L WhiteInstitute for Health Research, Kaiser Permanente Colorado, Aurora, Colorado, USA.
Andrea WilliamsSouthside Coalition of Community Health Centers.
Waverly WillisNo affiliations.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Taiki YamajiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
Susan T VadaparampilDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, USA.
Gail P JarvikDepartments of Medicine (Medical Genetics) and Genome Sciences, University of Washington Medical Center, Seattle, Washington, USA.
Andrea N Burnett-HartmanInstitute for Health Research, Kaiser Permanente Colorado, Denver, Colorado, USA.
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jane C FigueiredoDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Robert J MacInnisCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Julie R PalmerSlone Epidemiology Center at Boston University, Boston Massachusetts.
Stephanie L SchmitGenomic Sciences and Systems Biology, Cleveland Clinic, Cleveland, Ohio, USA.
Iris Landorp-VogelaarDepartment of Public Health, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MTranslational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8MWOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FUCHS, CHARLES S · 1991 to 2009
$41.8MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MA Follow-up Study for Causes of Cancer in Black WomenU01CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Kimberly A. Bertrand, Yvette C Cozier · 2017 to 2026
$24.0MMultiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MSouthern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0MVALIDATION OF A DIET HISTORY METHOD FOR EPIDEMIOLOGIC STUDIES OF CANCERP01CA033619 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1985 to 2010
$18.5MIntramural NIH HHS Z01 CP010200NCI NIH HHS K05 CA154337NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA015704NCI NIH HHS P50 CA285275NCI NIH HHS R01 CA042182NCI NIH HHS R01 CA126895NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA151993NCI NIH HHS R01 CA244588NCI NIH HHS R01 CA273198NCI NIH HHS R01 CA297681NCI NIH HHS R35 CA197735NCI NIH HHS R37 CA054281NCI NIH HHS R37 CA276306NCI NIH HHS U01 CA086308NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA164974NCI NIH HHS U01 CA167552NCI NIH HHS U01 CA202979NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG008657NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INHLBI NIH HHS HHSN268201700006CNIA NIH HHS U01 AG018033NIH HHS S10 OD028685WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
Abstract
Colorectal cancer (CRC) is a leading cause of cancer-related death, with incidence rising substantially among individuals under 50 years of age. Polygenic risk scores (PRS) hold promise for identifying high-risk individuals; when combined with lifestyle factors, they substantially improve prediction accuracy compared with models based on lifestyle factors alone. However, few clinical tools currently exist that facilitate this integrated, PRS-enhanced risk assessment. To bridge this gap, we developed
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.