Evidence map›Paper›PMID 42006741›Full record

ArticleJournal of aerosol science2026

Subject-Specific Whole-Lung CFPD Coupled with PBPK/PD to Predict Inhaled Bronchodilator Response in Asthmatic and Healthy Subjects.

Prathish K Rajaraman, Xuan Zhang, Alejandro P Comellas, Eric A Hoffman, Ching-Long Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of aerosol science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Prathish K RajaramanIIHR-Hydroscience & Engineering, University of Iowa, Iowa City, Iowa, USA.
Xuan ZhangIIHR-Hydroscience & Engineering, University of Iowa, Iowa City, Iowa, USA.
Alejandro P ComellasDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Eric A HoffmanDepartment of Radiology, University of Iowa, Iowa City, Iowa, USA.
Ching-Long LinIIHR-Hydroscience & Engineering, University of Iowa, Iowa City, Iowa, USA.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Deep Learning and Subtyping of Post-COVID-19 Lung Progression PhenotypesR01HL168116 · NHLBI · UNIVERSITY OF IOWA · PI CHING-LONG LIN · 2023 to 2026
$2.9M
FDA HHS U01 FD005837NHLBI NIH HHS R01 HL168116NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Accurate prediction of bronchodilator performance remains challenging. We present a coupled computational fluid and particle dynamics (CFPD) and physiologically-based pharmacokinetic/pharmacodynamics (PBPK/PD) framework that leverages subject-specific CT-derived airway trees and airflow distributions to model regional lung exposure and the resulting clinical effect, quantified as the change in Forced Expiratory Volume in 1 second (ΔFEV

Indexed as

AlbuterolComputational Fluid-Particle Dynamics (CFPD)Drug depositionDry Powder Inhaler (DPI)Metered Dose Inhaler (MDI)Pharmacodynamics (PD)Pharmacokinetic (PK)

Identifiers

PMID42006741
PMCPMC13089771

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.