FAP-targeting peptide-directed nanoprobes enable tumor microenvironment-activatable MR/NIRF imaging of breast cancer primary tumor and lung metastases.

Chunting Wang, Jingjing Hu, Yuelin Huang, Yanhong Chen, Ling Zhan, Huanhuan Liu, Defan Yao, Dengbin Wang

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Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Chunting WangDepartment of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

Jingjing HuDepartment of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

Yuelin HuangDepartment of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

Yanhong ChenDepartment of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

Ling ZhanDepartment of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

Huanhuan LiuDepartment of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

Defan YaoDepartment of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

Dengbin WangDepartment of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

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6 · The paper itself

Abstract

Fibroblast activation protein (FAP), a transmembrane serine protease overexpressed in tumor stroma, has emerged as a dual-purpose biomarker for cancer theranostics. Although FAP-targeting molecular imaging enables precise tumor visualization, its application for microenvironment-responsive detection of breast cancer metastases remains unexplored. To address this, we engineered acidic pH-responsive manganese dioxide (MnO

Indexed as

Breast cancerFibroblast activation proteinMRINIRFTumor microenvironment

Identifiers

PMID42006731

DOI10.1016/j.mtbio.2026.103064

PMCPMC13091518

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