Evidence map›Paper›PMID 42006631›Full record

ArticleThe World Allergy Organization journal2026

Effect of initiation treatment timing on efficacy of

Jingyun Li, Dandan Fang, Tingting Ma, Yan Liu, Xu Zhang, Shixian Liu, Chengshuo Wang, Luo Zhang, Yuan Zhang

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The World Allergy Organization journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05318157 (Long Term Efficacy of Artemisia Pollen Specific Allergen Immunotherapy in Patients With Seasonal Allergic Rhinitis), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05318157 phase4unknown statusnot on this map

Long Term Efficacy of Artemisia Pollen Specific Allergen Immunotherapy in Patients With Seasonal Allergic Rhinitis

TypeinterventionalSponsorBeijing Tongren HospitalRan2022 to 2024Enrolled150ConditionsAllergic RhinitisArmsAIT drops, Clarityne, Rhinocort and Emedastine Difumarate Eye Drops
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jingyun LiBeijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China.
Dandan FangBeijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China.
Tingting MaDepartment of Allergy, Allergy Institute, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Yan LiuDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, Beijing, China.
Xu ZhangBeijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China.
Shixian LiuBeijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China.
Chengshuo WangBeijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China.
Luo ZhangBeijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China.
Yuan ZhangBeijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Allergen specific immunotherapy (AIT) is a guideline-approved treatment that can modify the course of allergic rhinitis (AR). The treatment regimen for AIT in pollen-induced AR is more complex due to the impact of pollen exposure and there is no uniform recommendation on the time to initiate AIT for pollen-induced AR. Objective: The aim of this study was to investigate whether the initiation timing pre- or post-pollen season (PS) influence efficacy of Methods: This was an open-label multicenter clinical trial. We recruited eligible patients in March 2022 and November 2022 from 3 treatment centers, and initiated SLIT before and after the PS of Results: SLIT significantly alleviated symptoms and reduced medication use compared to control, regardless of whether initiation before or after the PS. Furthermore, the LMM indicated that initiation timing (pre-vs. post-season) did not significantly affect treatment efficacy. There was no significant interaction effect between initiation timing and treatment group. It was also shown that higher pollen concentration was significantly associated with worse symptom severity and increased medication use. Conclusion: This multi-center study further confirms the efficacy of SLIT for Clinical trial registrations: NCT05318157; Registered March 22, 2008.

Indexed as

Allergic rhinitisEfficacySublingual immunotherapyTime to treatment

Identifiers

PMID42006631
PMCPMC13091189

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.