ReviewJournal of pharmaceutical analysis2026
Role of oxidative stress in sepsis: Mechanisms, pathways, and therapeutic strategies.
Review in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical lipidomics in bacterial sepsis: a systematic review of serum and plasma evaluations.Metabolomics : Official journal of the Metabolomic Society · 2026Pooled it
- The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility.Current issues in molecular biology · 2026Review
- Autophagy-ferroptosis crosstalk in sepsis: metabolic pathways, redox injury, and host-directed antioxidant nanomedicine.Frontiers in immunology · 2026Review
- Visnagin Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting Oxidative Stress and Reducing Ferroptosis.International journal of medical sciences · 2026Article
- Oxidative Stress, Glutathione System Activity, and Zinc/Selenium Imbalance in Adult Measles of Varying Severity According to Vaccination Status.Infection and drug resistance · 2026Article
- Crosstalk between innate immune signaling pathways and integrated TLR, NLRP3 inflammasome, cGAS-STING, and NF-κB networks in sepsis.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis, a life-threatening condition caused by dysregulated host response to infection, leads to high morbidity and mortality, primarily due to sepsis-induced organ dysfunction. Oxidative stress, driven by excessive reactive oxygen species (ROS), plays a central role in sepsis pathophysiology, exacerbating inflammation, mitochondrial dysfunction, and cellular damage in multiple organs, including the heart, kidneys, liver, lungs, brain, and skeletal muscles. This review provides a comprehensive analysis of mechanisms by which oxidative stress contributes to sepsis-induced organ injury. Most current research examining the interplay between ROS, inflammation, mitochondrial dysfunction, and cell death pathways such as apoptosis, ferroptosis, and pyroptosis, are animal- or cell-based. Key signaling pathways, including nuclear factor κB (NF-κB), NLR family pyrin domain-containing 3 inflammasome (NLRP3), nuclear factor erythroid 2-related factor 2 (Nrf-2)/heme oxygenase-1 (HO-1), and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), are explored as potential therapeutic targets. This review also highlights the roles of mitochondrial quality control (MQC), autophagy, and noncoding RNAs in mitigating oxidative damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.