ArticleFrontiers in cardiovascular medicine2026
Association between the serum uric acid-to-creatinine ratio index and the risk of preeclampsia in advanced maternal age pregnant women: a retrospective cohort study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Immunometabolic Dysregulation in Preeclampsia: Emerging Roles of Inflammation, Insulin Resistance, Uric Acid, and the Gut Microbiome.Mediators of inflammation · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Advanced maternal age is associated with an increased risk of preeclampsia;however, reliable and easily accessible biomarkers for early risk stratification remain limited. The serum uric acid-to-creatinine ratio (SUA/sCr) has been proposed as an indicator of systemic oxidative stress, yet evidence regarding its association with preeclampsia remains limited. This study aimed to examine the association between SUA/sCr levels and the risk of preeclampsia among women of advanced maternal age. Methods: a total of 2,296 pregnant women aged ≥35 years were included in this retrospective cohort study. Multivariable logistic regression models were applied to evaluate the association between SUA/sCr and preeclampsia, with odds ratios (ORs) and 95% confidence intervals (CIs) reported. Restricted cubic spline regression was used to assess potential dose-response and non-linear relationships, and subgroup analyses were conducted to explore potential effect modification. Results: Preeclampsia occurred in 14.29% of the participants. After multivariable adjustment,each standard deviation increase in SUA/sCr was associated with a higher risk of preeclampsia(OR = 1.29; 95% CI: 1.13-1.47; Conclusion: Higher SUA/sCr levels in early pregnancy were associated with an increased risk of preeclampsia among women of advanced maternal age. These findings suggest that SUA/sCr may serve as a potential risk indicator in this population; however, the observed non-linear relationship should be interpreted cautiously and warrants further prospective validation.
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