ArticleEJIFCC2026
Correlation of D-dimer Measurement Values Using Quantum Dots Fluorescence Immunochromatographic Assay and Latex-Enhanced Immunoturbidimetric Assay.
Article in EJIFCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Introduction: D-dimer, a fibrin degradation product, is widely used in the diagnosis of thrombotic disorders and in clinical decision-making. Quantum dots (QDs) fluorescence immunochromatography has emerged as a rapid method for detecting protein biomarkers; however, comparative data with the established latex-enhanced immunoturbidimetric assay remain limited. Methods: A laboratory-based method comparison study was conducted using 80 consecutively collected plasma samples from patients at Dr. Soetomo General Academic Hospital, Surabaya. D-dimer levels were measured using a QDs fluorescence immunochromatography assay (QD-S2000, Vazyme, China) and a latex-enhanced immunoturbidimetric assay (Sysmex CS-2500, Sysmex Corporation, Japan).Correlation and agreement between methods were assessed using Spearman correlation analysis and Bland-Altman plots. Results: Among the 80 samples (60% female, 40% male), a very strong correlation was observed between the two methods (Spearman r = 0.951, p < 0.001). Bland-Altman analysis demonstrated good agreement, with most data points falling within the 95% limits of agreement. Although the QDs fluorescence immunochromatography method consistently produced higher absolute D-dimer values, both assays showed comparable trends across the measurement range. Conclusion: QDs fluorescence immunochromatography and the latex-enhanced immunoturbidimetric assay demonstrated strong correlation and acceptable agreement in D-dimer measurement. Despite yielding higher absolute values, the QDs-based method showed consistent performance, supporting its potential as a reliable and rapid alternative for clinical D-dimer assessment.
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